Oscar Isaac Interesting Person #1 (voice)
Hailee Steinfeld Gwen Stacy (voice)
Nicolas Cage Spider-Man Noir (voice)
Stan Lee Executive Producer, Stan (voice), Thanks, In Memory Of, Original Film Writer
Lily Tomlin Aunt May (voice)
Kathryn Hahn Doc Ock (voice)
Liev Schreiber Wilson Fisk (voice)
Chris Pine Peter Parker (voice)
Zoë Kravitz Mary Jane (voice)
Lake Bell Vanessa Fisk (voice)
Courtney Peldon Additional Voices (voice)
Greta Lee Interesting Person #2 (voice)
Darcy Rose Byrnes Additional Voices (voice)
Mahershala Ali Uncle Aaron (voice)
Luna Lauren Velez Rio Morales (voice)
John Mulaney Spider-Ham (voice)
Jake Johnson Peter B. Parker (voice)
Post Malone Brooklyn Bystander (voice)
Brian Tyree Henry Jefferson Davis (voice)
Jorma Taccone Green Goblin / Last Dude (voice)
Rodney Rothman Screenplay, Director
Kimiko Glenn Peni Parker (voice)
Paul Lasaine Visual Development
Nicholas St. Clair Animation
Shameik Moore Miles Morales (voice)
Scott Menville Additional Voices (voice)
Warren Sroka Additional Voices (voice)
Natalie Morales Miss Calleros (voice)
Rick Owens Foley Artist
Geoffrey G. Rubay Supervising Sound Editor
Arthur Ortiz Additional Voices (voice)
Bob Persichetti Director
Kier Lehman Music Supervisor
Christian Hejnal Co-Producer
Oscar Camacho Additional Voices (voice)
Gary A. Hecker Foley Artist
Will Allegra Executive Producer
David Gimenez Animation
Marvin Jones III Tombstone (voice)
Theresa Bentz Co-Producer
Bridget Hoffman Additional Voices (voice)
Phil Lord Producer, Screenplay, Story
Nick Jaine Brooklyn Visions Teacher (voice)
Cody Cameron Story Artist
Avi Arad Producer
Rif Hutton Additional Voices (voice)
Nathan Dillow Animation
André Lacroix Animation
Juan Pope Additional Voices (voice)
Christopher Miller Producer, Additional Voices (voice)
Ian McQue Thanks
Nideep Varghese Animation
Joseph Izzo Production Manager, Brooklyn Visions Teacher (voice)
Daniel Pemberton Original Music Composer
Peter Ramsey Director
Mary Hidalgo Casting
Dean Gordon Art Direction
Laide Agunbiade Lighting Artist, Compositing Artist
Joaquín Cosío Scorpion (voice)
Dennis Singletary Additional Voices (voice)
Amy Pascal Producer
Omar Smith Character Designer
Jacqueline Pinol Additional Voices (voice)
Curt Schulkey Supervising Sound Editor
Agustín Ross Beraldi Animation
Shiyoon Kim Character Designer
Jeffrey M. Thompson Visual Development
Stephan Franck Story Artist
Kasey Fagerquist Story Artist
Gabe Hordos Visual Development
John Pospisil Sound Designer
Melissa Sturm Additional Voices (voice)