Nicolas Cage Spider-Man Noir (voice)
Oscar Isaac Interesting Person #1 (voice)
Greta Lee Interesting Person #2 (voice)
Lily Tomlin Aunt May (voice)
Hailee Steinfeld Gwen Stacy (voice)
Liev Schreiber Wilson Fisk (voice)
Kathryn Hahn Doc Ock (voice)
Lake Bell Vanessa Fisk (voice)
Chris Pine Peter Parker (voice)
Zoë Kravitz Mary Jane (voice)
Bridget Hoffman Additional Voices (voice)
Stan Lee Stan (voice), In Memory Of, Executive Producer, Original Film Writer, Thanks
Courtney Peldon Additional Voices (voice)
Avi Arad Producer
Darcy Rose Byrnes Additional Voices (voice)
Al Rodrigo Additional Voices (voice)
Luna Lauren Velez Rio Morales (voice)
Jake Johnson Peter B. Parker (voice)
Cody Cameron Story Artist
Mahershala Ali Uncle Aaron (voice)
Post Malone Brooklyn Bystander (voice)
John Mulaney Spider-Ham (voice)
Andy Sisul Sound Effects Editor
Rodney Rothman Screenplay, Director
Christopher Miller Additional Voices (voice), Producer
Paul Lasaine Visual Development
Katie Greathouse Music Editor
Jorma Taccone Green Goblin / Last Dude (voice)
Shameik Moore Miles Morales (voice)
Warren Sroka Additional Voices (voice)
Phil Lord Producer, Screenplay, Story
Natalie Morales Miss Calleros (voice)
Rick Owens Foley Artist
Kimiko Glenn Peni Parker (voice)
Geoffrey G. Rubay Supervising Sound Editor
Brian Tyree Henry Jefferson Davis (voice)
Kier Lehman Music Supervisor
Amy Pascal Producer
Christian Hejnal Co-Producer
Marvin Jones III Tombstone (voice)
Theresa Bentz Co-Producer
Nick Jaine Brooklyn Visions Teacher (voice)
Gary A. Hecker Foley Artist
Scott Menville Additional Voices (voice)
Steve Ditko In Memory Of, Original Film Writer, Thanks
Arthur Ortiz Additional Voices (voice)
David Gimenez Animation
Bob Persichetti Director
Dean Gordon Art Direction
Laide Agunbiade Lighting Artist, Compositing Artist
Joaquín Cosío Scorpion (voice)
Dennis Singletary Additional Voices (voice)
Jacqueline Pinol Additional Voices (voice)
Peter Ramsey Director
Michelle Jubilee Gonzalez Additional Voices (voice)
Curt Schulkey Supervising Sound Editor
Jeffrey M. Thompson Visual Development
Kasey Fagerquist Story Artist
Gabe Hordos Visual Development
Melissa Sturm Additional Voices (voice)
John Pospisil Sound Designer
Rif Hutton Additional Voices (voice)
Shiyoon Kim Character Designer
Justin K. Thompson Production Design
Alberto Mielgo Other
Nideep Varghese Animation
Brian Michael Bendis Executive Producer
Jason Linere-White Additional Voices (voice)
Craig Kellman Character Designer
June Christopher Additional Voices (voice)
Noëlle Triaureau Visual Development
Mary Hidalgo Casting