Nicolas Cage Spider-Man Noir (voice)
Oscar Isaac Interesting Person #1 (voice)
Mahershala Ali Uncle Aaron (voice)
Hailee Steinfeld Gwen Stacy (voice)
Chris Pine Peter Parker (voice)
Liev Schreiber Wilson Fisk (voice)
Jake Johnson Peter B. Parker (voice)
Zoë Kravitz Mary Jane (voice)
Phil Lord Story, Screenplay, Producer
Stan Lee Thanks, In Memory Of, Stan (voice), Executive Producer
Kathryn Hahn Doc Ock (voice)
John Mulaney Spider-Ham (voice)
Greta Lee Interesting Person #2 (voice)
Natalie Morales Miss Calleros (voice)
Jaden Smith Songs
Luna Lauren Vélez Rio Morales (voice)
Lake Bell Vanessa Fisk (voice)
Scott Menville Additional Voices (voice)
Christopher Miller Producer, Additional Voices (voice)
Shameik Moore Miles Morales (voice)
Alex Hirsch Story Coordinator
Marvin Jones III Tombstone (voice)
Kimiko Glenn Peni Parker (voice)
Post Malone Songs, Brooklyn Bystander (voice)
Darcy Rose Byrnes Additional Voices (voice)
Nicki Minaj Songs
Brian Tyree Henry Jefferson Davis (voice)
Jorma Taccone Green Goblin / Last Dude (voice)
Steve Ditko In Memory Of, Thanks
Jacqueline Pinol Additional Voices (voice)
Lily Tomlin Aunt May (voice)
Amy Pascal Producer
Gary A. Hecker Foley Artist
Lex Lang Additional Voices (voice)
Rif Hutton Additional Voices (voice)
Rodney Rothman Screenplay, Director
Daniel Pemberton Original Music Composer
Pierre Perifel Animation
Mary Hidalgo Casting
Chrystee Pharris Additional Voices (voice)
Joaquín Cosío Scorpion (voice)
Melissa Sturm Additional Voices (voice)
Justin Shenkarow Additional Voices (voice)
Cody Cameron Story Artist
Avi Arad Producer
Caitlin McKenna Additional Voices (voice), ADR Voice Casting
Christopher S. Aud Sound Effects Editor
Bridget Hoffman Additional Voices (voice)
Ty Dolla Sign Songs
Shakira Ja'nai Paye Additional Voices (voice)
Peter Ramsey Director
David Werntz Sound Effects Editor
Michael Semanick Sound Re-Recording Mixer
Ruth Zalduondo Additional Voices (voice)
Al Rodrigo Additional Voices (voice)
Justin K. Thompson Production Design
Courtney Peldon Additional Voices (voice)
June Christopher Additional Voices (voice)
Vince Staples Songs
Stephan Franck Story Artist
Edwin H. Bravo Brooklyn Visions Security Guard (voice)
Tony Lamberti Sound Re-Recording Mixer
Devika Parikh Additional Voices (voice)
Laura H. Han Animation
Terrence Hardy Jr. Additional Voices (voice)
Claudia Choi Brooklyn Visions Teacher (voice)
Randy K. Singer Foley Mixer
Arthur Ortiz Additional Voices (voice)
Lil Wayne Songs
Dennis Singletary Additional Voices (voice)
Craig Kellman Character Designer
Brian Michael Bendis Executive Producer