Nicolas Cage Spider-Man Noir (voice)
Oscar Isaac Interesting Person #1 (voice)
Hailee Steinfeld Gwen Stacy (voice)
Kathryn Hahn Doc Ock (voice)
Stan Lee Thanks, In Memory Of, Stan (voice), Executive Producer
Zoë Kravitz Mary Jane (voice)
Mahershala Ali Uncle Aaron (voice)
Chris Pine Peter Parker (voice)
Liev Schreiber Wilson Fisk (voice)
Jaden Smith Songs
Lily Tomlin Aunt May (voice)
Christopher Miller Producer, Additional Voices (voice)
Phil Lord Story, Screenplay, Producer
Jake Johnson Peter B. Parker (voice)
Lake Bell Vanessa Fisk (voice)
Greta Lee Interesting Person #2 (voice)
Natalie Morales Miss Calleros (voice)
Luna Lauren Vélez Rio Morales (voice)
Shameik Moore Miles Morales (voice)
Brian Tyree Henry Jefferson Davis (voice)
John Mulaney Spider-Ham (voice)
Darcy Rose Byrnes Additional Voices (voice)
Nicki Minaj Songs
Steve Ditko In Memory Of, Thanks
Kimiko Glenn Peni Parker (voice)
Alex Hirsch Story Coordinator
Avi Arad Producer
Jorma Taccone Green Goblin / Last Dude (voice)
Scott Menville Additional Voices (voice)
Post Malone Songs, Brooklyn Bystander (voice)
Daniel Pemberton Original Music Composer
Amy Pascal Producer
Justin K. Thompson Production Design
Marvin Jones III Tombstone (voice)
Joaquín Cosío Scorpion (voice)
Rodney Rothman Screenplay, Director
Bob Persichetti Director
Tony Lamberti Sound Re-Recording Mixer
Michael Semanick Sound Re-Recording Mixer
Justin Shenkarow Additional Voices (voice)
Peter Ramsey Director
Lex Lang Additional Voices (voice)
Patrick O'Keefe Art Direction
Melissa Sturm Additional Voices (voice)
Gary A. Hecker Foley Artist
Kim Yarbrough Scientist in Cafeteria (voice)
Kier Lehman Music Supervisor
Jacqueline Pinol Additional Voices (voice)
Cody Cameron Story Artist
Pierre Perifel Animation
Ty Dolla Sign Songs
Rif Hutton Additional Voices (voice)
Chrystee Pharris Additional Voices (voice)
Lil Wayne Songs
Mary Hidalgo Casting
Alberto Mielgo Other
Pawel Grochola Effects Supervisor
Bridget Hoffman Additional Voices (voice)
Miles Thompson Story Artist
Riccardo Durante Story Artist
Shaboozey Songs
Vince Staples Songs
Caitlin McKenna Additional Voices (voice), ADR Voice Casting
Oscar Camacho Additional Voices (voice)
Dean Gordon Art Direction
Shakira Ja'nai Paye Additional Voices (voice)
Jane Wu Story Artist
Mimi Davila Brooklyn Visions Student (voice)
Dylan Reid Supervising Animator
Christina Steinberg Producer
June Christopher Additional Voices (voice)
Courtney Peldon Additional Voices (voice)