George Clooney Frank Walker
Lochlyn Munro Uncle Anthony (uncredited)
Judy Greer Jenny Newton
Britt Robertson Casey Newton
Hugh Laurie David Nix
Keegan-Michael Key Hugo
Kathryn Hahn Ursula
Brad Bird Producer, Story, Screenplay, Director
Chris Bauer Frank's Dad
Raffey Cassidy Athena
Marcus Rosner Handsome Harry (uncredited)
Patrick Sabongui Eiffel Tower Guard #1
Jedidiah Goodacre Jetpack Buddy
Pierce Gagnon Nate Newton
Tim McGraw Eddie Newton
Michael Giacchino Original Music Composer, Small World Operator
Garry Chalk Jail Desk Jockey
Monique Ganderton Dave Clark #1 (uncredited), Stunts
Shiloh Nelson Young Casey Newton
Matthew MacCaull Dave Clark
Damon Lindelof Producer, Story, Screenplay
Darren Shahlavi Tough Guard
Paul McGillion English Teacher
Gary Rydstrom Sound Re-Recording Mixer
Tom Butler Police Captain
Matthew Kevin Anderson Bus Driver
Walter Murch Editor
Jaeda Lily Miller Young Casey (uncredited)
Aliyah O'Brien Functionary (uncredited)
Thomas Robinson Young Frank Walker
Garvin Cross Stunts
Joey Box Stunt Coordinator
Loyd Bateman Stunts
Krista Bell Stunt Double
Erik Messerschmidt Gaffer
Manoj Sood Economics Teacher (uncredited)
Xantha Radley History Teacher
Bernard Bellew Executive Producer
Alex Barima Jetpack Buddy
Ed Anders Stunts
Luke Freeborn Art Direction
Gwendolyn Yates Whittle Supervising Sound Editor
Claudio Miranda Director of Photography
Amy Esterle Greyhound Girl (uncredited)
Eddie Perez Dave Clark #2 (uncredited)
David Nykl Science Teacher
Tim Perez Deputy
Teresa Eckton Foley
Clint Carleton Pierre Clark (uncredited), Stunt Double
Hans Bjerno Helicopter Camera
Robert Alonzo Stunt Coordinator
BJ McDonnell Steadicam Operator
Fraser Corbett Jensen
Todd Cherniawsky Art Direction
Janene Carleton Stunts
Paul Anthony Thick Glasses (uncredited)
Ellen Marguerite Cullivan Neighbor (uncredited)
Owen Walstrom Stunts
Jennifer Page Casting
Dagan Nish Jail Punk
Charles Leitrants Construction Coordinator
Michael Ralla Digital Compositor
Juan Peralta Sound Re-Recording Mixer
Darien Provost Mikey (uncredited)
Chris Castaldi First Assistant Director
Kyrsten Mate Sound Designer
Parm Soor Astronaut's Father
Kory Grim Dave Clark Henchman (uncredited)
Barbara Keegan World's Fair Patron (uncredited)
Michael Ray Davis Lonely Man (uncredited)
Tommy Lentsch Driver on the street (uncredited)
Deborah Rutherford Makeup Artist