George Clooney Frank Walker
Judy Greer Jenny Newton
Lochlyn Munro Uncle Anthony (uncredited)
Britt Robertson Casey Newton
Hugh Laurie David Nix
Keegan-Michael Key Hugo
Kathryn Hahn Ursula
Brad Bird Producer, Story, Screenplay, Director
Chris Bauer Frank's Dad
Marcus Rosner Handsome Harry (uncredited)
Patrick Sabongui Eiffel Tower Guard #1
Jedidiah Goodacre Jetpack Buddy
Pierce Gagnon Nate Newton
Tim McGraw Eddie Newton
Raffey Cassidy Athena
Michael Giacchino Original Music Composer, Small World Operator
Garry Chalk Jail Desk Jockey
Shiloh Nelson Young Casey Newton
Darren Shahlavi Tough Guard
Monique Ganderton Dave Clark #1 (uncredited), Stunts
Damon Lindelof Producer, Story, Screenplay
Gary Rydstrom Sound Re-Recording Mixer
Matthew Kevin Anderson Bus Driver
Tom Butler Police Captain
Matthew MacCaull Dave Clark
Jaeda Lily Miller Young Casey (uncredited)
Paul McGillion English Teacher
Aliyah O'Brien Functionary (uncredited)
Thomas Robinson Young Frank Walker
Robert Alonzo Stunt Coordinator
Loyd Bateman Stunts
Erik Messerschmidt Gaffer
Manoj Sood Economics Teacher (uncredited)
Walter Murch Editor
Xantha Radley History Teacher
Alex Barima Jetpack Buddy
Joey Box Stunt Coordinator
Garvin Cross Stunts
Gwendolyn Yates Whittle Supervising Sound Editor
Claudio Miranda Director of Photography
Amy Esterle Greyhound Girl (uncredited)
Janene Carleton Stunts
David Nykl Science Teacher
Tim Perez Deputy
Luke Freeborn Art Direction
Eddie Perez Dave Clark #2 (uncredited)
BJ McDonnell Steadicam Operator
Hans Bjerno Helicopter Camera
Paul Anthony Thick Glasses (uncredited)
Owen Walstrom Stunts
Ellen Marguerite Cullivan Neighbor (uncredited)
Dagan Nish Jail Punk
Jennifer Page Casting
Charles Leitrants Construction Coordinator
Corinne Clark Casting
Krista Bell Stunt Double
Lin MacDonald Set Decoration
Juan Peralta Sound Re-Recording Mixer
Darien Provost Mikey (uncredited)
Priya Rajaratnam Young Astronaut
Chris Castaldi First Assistant Director
Kyrsten Mate Sound Designer
Parm Soor Astronaut's Father
Todd Cherniawsky Art Direction
Fraser Corbett Jensen
Barbara Keegan World's Fair Patron (uncredited)
Michael Ray Davis Lonely Man (uncredited)
Tommy Lentsch Driver on the street (uncredited)
Deborah Rutherford Makeup Artist
Jeffrey Kurland Costume Design
PewDiePie PewDiePie (uncredited)
Catherine Michaud Young Attendee (uncredited)