Hannah Waddingham Jezebeth (voice)
Octavia Spencer Asmodius (voice)
Rihanna Producer, Original Music Composer, Smurfette (voice)
Kurt Russell Ron (voice)
John Goodman Papa Smurf (voice)
Sandra Oh Moxie Smurf (voice)
Nick Offerman Ken (voice)
Natasha Lyonne Mama Poot (voice)
Amy Sedaris Jaunty (voice)
Nick Kroll Chernobog (voice)
Xolo Maridueña Brainy Smurf (voice)
Conrad Vernon Butler (voice)
Chris Miller Director, Grouchy Smurf / Camouflage Smurf (voice)
James Corden No Name (voice)
Billie Lourd Worry Smurf (voice)
JP Karliak Gargamel / Razamel (voice)
Alex Winter Hefty Smurf (voice)
Pete Chiappetta Executive Producer
Jimmy Kimmel Tardigrade (voice)
Maya Erskine Vanity Smurf (voice)
Pam Brady Writer
Peyo Characters
Gary Rizzo Sound Re-Recording Mixer
Dan Levy Joel (voice)
Tom Myers Supervising Sound Editor
Anthony Tittanegro Executive Producer
Daisuke Tsuji No Name Anime (voice)
Randy Thom Sound Designer
Chris Prynoski Quiet Smurf / Way Back There Smurf / Shark Taming Smurf (voice)
Marshmello Turtle (voice)
Andrew Lary Executive Producer
Peter Lyons Collister Director of Photography, Second Unit Director
Henry Jackman Original Music Composer
Rachel Butera Azrael / List Maker Smurf (voice)
Keisuke Hoashi Razamel Anime (voice)
Yuuki Luna Smurfette Anime (voice)
Matthew Landon Editor
Chris Kazmier Visual Effects Supervisor
Coya Elliott ADR Editor
DJ Snake DJ Snake (voice)
Danilo Bollettini Special Effects Technician
Ryan Harris Producer
Gwyn Sannia First Assistant Director
Jonny Manganello Baker Smurf (voice)
Marco Furbatto Art Direction
Rosario Pucciarelli Second Assistant Director
Tyler Peterson Bellhop (voice)
Margaret Wuller Art Direction
Andrew Babick Visual Effects Supervisor
Tyran "Ty Ty" Smith Producer
Ryan Naylor Calendar Smurf (voice)
Arianna Palmucci Hair Designer
Léa Elui Featured Paris Disco Dancer (voice)
Maurizio Tiella Camera Operator
Jay Brown Producer
Spencer X Sound Effects Smurf (voice)
Daniela Zorzetto Set Decoration
Hugo Miller Clumsy Smurf (voice)
Edoardo Galeone Second Second Assistant Director
Giulia De Stefano Set Decoration
Flavia Battista Third Assistant Director