John Goodman Papa Smurf (voice)
Kurt Russell Ron (voice)
Hannah Waddingham Jezebeth (voice)
Octavia Spencer Asmodius (voice)
Amy Sedaris Jaunty (voice)
James Corden No Name (voice)
Rihanna Smurfette (voice), Producer, Songs
Sandra Oh Moxie Smurf (voice)
Alex Winter Hefty Smurf (voice)
Nick Offerman Ken (voice)
JP Karliak Gargamel / Razamel (voice)
Natasha Lyonne Mama Poot (voice)
Chris Miller Director
Xolo Mariduena Brainy Smurf (voice)
Maya Erskine Vanity Smurf (voice)
Nick Kroll Chernobog (voice)
Jimmy Kimmel Tardigrade (voice)
Gary Rizzo Sound Re-Recording Mixer
Billie Lourd Worry Smurf (voice)
Dan Levy Joel (voice)
Tom Myers Supervising Sound Editor
Randy Thom Sound Designer
Coya Elliott ADR Editor
Henry Jackman Original Music Composer
Pam Brady Writer
Ryan Harris Producer
Peyo Characters
Daniel Laurie ADR Supervisor
Marshmello Turtle (voice)
Spencer X Sound Effects Smurf (voice)
Tyran "Ty Ty" Smith Producer
Jay Brown Producer