Jennifer Love Hewitt Liz
Alan Cumming Persnikitty (voice)
David Eigenberg Nermal (voice)
Mark Christopher Lawrence Christopher Mello
Bill Murray Garfield (voice)
Stephen Tobolowsky Happy Chapman
Breckin Meyer Jon
Richard Kind Dad Rat (voice)
Brad Garrett Luca (voice)
Debra Messing Arlene (voice)
Alyson Stoner Kid Rat (voice)
Michele Imperato Stabile Co-Producer
Jimmy Kimmel Spanky (voice)
Crystal the Monkey Pet Monkey (uncredited)
Barbara Anne Klein Stunts
Nick Cannon Louis (voice)
Daamen J. Krall Announcer
Mel Rodriguez Security Officer
Juliette Goglia Little Girl
Christophe Beck Original Music Composer
Joel Cohen Screenplay
Dean Cundey Director of Photography
Eve Brent Mrs. Baker
Michael Monks Deputy Hopkins
Jerry Hauck Cop
Alec Sokolow Screenplay
Jim Davis Comic Book
John Davis Producer
Evan Arnold Wendell
Peter Hewitt Director
Dan DeLeeuw Visual Effects Supervisor
Bill Hoag Roy the Lodge Member
Ben Kronen Older Man
Alec Hammond Production Design
Risa Bramon Garcia Casting
Angie Jones Animation
Mathew Krentz Compositing Artist
Peter E. Berger Editor
Neil Machlis Executive Producer
Michael A. Stevenson Editor
Brennan Dufresne Casting
Brian Manis Executive Producer
Vanessa Campbell Miss Ace Hardware
Glenn Derry Pre-Visualization Supervisor
Marie France Costume Design
Randee Reicher Dog Owner #2
Rufus Gifford Dog Owner #1
Susan Moore Dog Owner #4
Joseph Edward Taylor Frank
Ryan McKasson Dog Owner #3