Brad Garrett Luca (voice)
Alan Cumming Persnikitty (voice)
Jennifer Love Hewitt Liz
Richard Kind Dad Rat (voice)
Bill Murray Garfield (voice)
Stephen Tobolowsky Happy Chapman
Debra Messing Arlene (voice)
David Eigenberg Nermal (voice)
Nick Cannon Louis (voice)
Alyson Stoner Kid Rat (voice)
Jimmy Kimmel Spanky (voice)
Eve Brent Mrs. Baker
Breckin Meyer Jon
Alec Sokolow Screenplay
Mel Rodriguez Security Officer
Joel Cohen Screenplay
Dean Cundey Director of Photography
John Davis Producer
Juliette Goglia Little Girl
Jim Davis Comic Book
Michael Monks Deputy Hopkins
Crystal the Monkey Pet Monkey (uncredited)
Christophe Beck Original Music Composer
Dan DeLeeuw Visual Effects Supervisor
Daamen J. Krall Announcer
Jerry Hauck Cop
Evan Arnold Wendell
Mark Christopher Lawrence Christopher Mello
Barbara Anne Klein Stunts
Mathew Krentz Compositing Artist
Glenn Derry Pre-Visualization Supervisor
Alec Hammond Production Design
Angie Jones Animation
Peter Hewitt Director
Michele Imperato Stabile Co-Producer
Bill Hoag Roy the Lodge Member
Ben Kronen Older Man
Risa Bramon Garcia Casting
Peter E. Berger Editor
Neil Machlis Executive Producer
Michael A. Stevenson Editor
Brennan Dufresne Casting
Brian Manis Executive Producer
Vanessa Campbell Miss Ace Hardware
Marie France Costume Design
Randee Reicher Dog Owner #2
Rufus Gifford Dog Owner #1
Susan Moore Dog Owner #4
Joseph Edward Taylor Frank
Ryan McKasson Dog Owner #3