Alan Cumming Persnikitty (voice)
David Eigenberg Nermal (voice)
Jennifer Love Hewitt Liz
Bill Murray Garfield (voice)
Breckin Meyer Jon
Brad Garrett Luca (voice)
Debra Messing Arlene (voice)
Richard Kind Dad Rat (voice)
Stephen Tobolowsky Happy Chapman
Alyson Stoner Kid Rat (voice)
Juliette Goglia Little Girl
Nick Cannon Louis (voice)
Jimmy Kimmel Spanky (voice)
Jim Davis Comic Book
Joel Cohen Screenplay
Mel Rodriguez Security Officer
Jerry Hauck Cop
Alec Sokolow Screenplay
John Davis Producer
Christophe Beck Original Music Composer
Michael Monks Deputy Hopkins
Crystal the Monkey Pet Monkey (uncredited)
Dean Cundey Director of Photography
Mark Christopher Lawrence Christopher Mello
Eve Brent Mrs. Baker
Peter Hewitt Director
Evan Arnold Wendell
Bill Hoag Roy the Lodge Member
Dan DeLeeuw Visual Effects Supervisor
Ben Kronen Older Man
Barbara Anne Klein Stunts
Mathew Krentz Compositing Artist
Daamen J. Krall Announcer
Risa Bramon Garcia Casting
Michele Imperato Stabile Co-Producer
Glenn Derry Pre-Visualization Supervisor
Peter E. Berger Editor
Alec Hammond Production Design
Neil Machlis Executive Producer
Michael A. Stevenson Editor
Angie Jones Animation
Brennan Dufresne Casting
Brian Manis Executive Producer
Vanessa Campbell Miss Ace Hardware
Marie France Costume Design
Randee Reicher Dog Owner #2
Rufus Gifford Dog Owner #1
Susan Moore Dog Owner #4
Joseph Edward Taylor Frank
Ryan McKasson Dog Owner #3