Jennifer Love Hewitt Liz
Brad Garrett Luca (voice)
Bill Murray Garfield (voice)
Alan Cumming Persnikitty (voice)
Debra Messing Arlene (voice)
Richard Kind Dad Rat (voice)
Stephen Tobolowsky Happy Chapman
Alyson Stoner Kid Rat (voice)
David Eigenberg Nermal (voice)
Nick Cannon Louis (voice)
Breckin Meyer Jon
Jimmy Kimmel Spanky (voice)
Mel Rodriguez Security Officer
Eve Brent Mrs. Baker
Joel Cohen Screenplay
Alec Sokolow Screenplay
Juliette Goglia Little Girl
John Davis Producer
Jim Davis Comic Book
Risa Bramon Garcia Casting
Christophe Beck Original Music Composer
Michael Monks Deputy Hopkins
Mark Christopher Lawrence Christopher Mello
Dean Cundey Director of Photography
Evan Arnold Wendell
Bill Hoag Roy the Lodge Member
Jerry Hauck Cop
Barbara Anne Klein Stunts
Crystal the Monkey Pet Monkey (uncredited)
Mathew Krentz Compositing Artist
Neil Machlis Executive Producer
Brennan Dufresne Casting
Michele Imperato Stabile Co-Producer
Daamen J. Krall Announcer
Dan DeLeeuw Visual Effects Supervisor
Glenn Derry Pre-Visualization Supervisor
Peter E. Berger Editor
Angie Jones Animation
Alec Hammond Production Design
Peter Hewitt Director
Randee Reicher Dog Owner #2
Ben Kronen Older Man
Michael A. Stevenson Editor
Brian Manis Executive Producer
Vanessa Campbell Miss Ace Hardware
Marie France Costume Design
Rufus Gifford Dog Owner #1
Susan Moore Dog Owner #4
Joseph Edward Taylor Frank
Ryan McKasson Dog Owner #3