Tom Hanks Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Hugo Weaving Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Natalie Portman Thanks
David Gyasi Autua / Lester Rey / Duophsyte
Hugh Grant Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
Halle Berry Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
James D'Arcy Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
Jim Broadbent Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Zhu Zhu Megan Sixsmith / 12th Star Clone
Keith David Kupaka / Joe Napier / An-kor Apis / Prescient
Zhou Xun Talbot / Hotel Manager / Yoona-939 / Rose
Lana Wachowski Producer, Director, Screenplay
Susan Sarandon Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Bae Doona Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Ben Whishaw Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
Jim Sturgess Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law
Alistair Petrie Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman
Martin Wuttke Mr. Boerhaave / Guard / Leary the Healer
Lilly Wachowski Director, Screenplay, Producer
David Scheunemann Art Direction
Tom Tykwer Director, Music, Producer, Original Music Composer, Screenplay
Sylvestra Le Touzel Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership
Andrew Havill Mr. Hotchkiss
Götz Otto Groundsman Withers
Marcus Loges Co-Producer
Dan Glass Visual Effects
Daniele Massaccesi Camera Operator, Steadicam Operator
Kym Barrett Costume Design
Johnny Klimek Original Music Composer
Terry Needham First Assistant Director
Niall Greig Fulton Haskell Moore's Dinner Guest / Mozza Hoggins
Phong Giang Stunts
Ben O'Brien Compositing Supervisor
Amanda Walker Veronica
Liam Byrne Armorer
Robert Fyfe Old Salty Dog / Mr. Meeks / Prescient 1
Louis Dempsey Haskell Moore's Dinner Guest / Jarvis Hoggins
Lucinda Syson Casting
Reinhold Heil Original Music Composer
Siân Richards Makeup Artist
Jeremy Braben Aerial Director of Photography
Daniela Skala Makeup Artist, Hairstylist
Douglas Bloom CG Supervisor
John Chong Executive Producer
Steve Summersgill Art Direction
Lars Ginzel Sound Re-Recording Mixer
Can Aydin Stunts
Philip Lee Executive Producer
Pierre-Yves Gayraud Costume Design
Frank Kruse Sound Designer
Michael Miller ADR Mixer
Florian Emmerich Camera Operator
Sherry Hitch Digital Compositor
Ralph Riach Ernie
Claudia Heinz Stunt Double
David Mitchell Union Spy, Novel
Jon Donahue Moore's Accountant / Finch's Friend (uncredited)
Paula Price Makeup Artist, Hairstylist
Lora Kennedy Casting
Jeremy Woodhead Prosthetic Designer, Makeup Designer
Olivier Dumont Visual Effects Art Director
Marie Charlotte Matthaei Set Dresser
Chris Lyons Special Effects Makeup Artist
Allison Paul Visual Effects Coordinator
Hanse Warns Foley Mixer
Cristina Patterson Contact Lens Designer, Contact Lens Painter
Gary McCormack Crane Operator
Roberto Malerba Co-Producer
Daniel Weis ADR Recordist
Jay Maidment Still Photographer
John Toll Director of Photography
Stephane Ceretti Visual Effects Supervisor