Christina Ricci Vexy (voice)
Brendan Gleeson Victor Doyle
Neil Patrick Harris Patrick Winslow
Alan Cumming Gutsy Smurf (voice)
George López Grouchy Smurf (voice)
Hank Azaria Gargamel
Jacob Tremblay Blue Winslow
Fred Armisen Brainy Smurf (voice)
Katy Perry Smurfette (voice)
Frank Welker Azrael (voice)
Kenan Thompson Greedy Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Jayma Mays Grace Winslow
Paul Reubens Jokey Smurf (voice)
Patrick Sabongui Candy Man
JB Smoove Hackus (voice)
Shaquille O'Neal Smooth Smurf (voice)
B.J. Novak Baker Smurf (voice)
Mario López Social Smurf (voice)
John Kassir Crazy Smurf (voice)
John Oliver Vanity Smurf (voice)
Gary Basaraba Hefty Smurf (voice)
Alain Moussi Stunts
Tom Kane Narrator Smurf (voice)
Becky G Songs
Jimmy Kimmel Passive-Aggressive Smurf (voice)
Raja Gosnell Director
Adam Wylie Panicky Smurf (voice)
Joel McCrary Farmer Smurf (voice)
Mylène Dinh-Robic Hotel Assistant Manager
Shaun White Clueless Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Karey Kirkpatrick Screenplay
J. David Stem Story, Screenplay
James A. Woods Peanut Father
Jay Scherick Screenplay, Story
Carolina Bartczak Peanut Mom
Erika Rosenbaum Pregnant Mom
Beatrice Rosen Pregnant Model
Patricia Summersett Smurf Voice #2 (voice)
David N. Weiss Screenplay, Story
David Ronn Screenplay, Story
Peyo Characters, Comic Book
G.A. Aguilar Second Unit Director, Stunt Coordinator
Heitor Pereira Original Music Composer
Randi Wells Casting
Ruth Chiang Single Mom
Michael Parks Animation
Jonathan Winters Papa Smurf (voice)
David Rubin Casting
Dusan Dukic Curious Dad
Martin Doepner Additional Third Assistant Director
Pascale Deschênes Set Decoration
Vincent Gingras-Liberali Art Direction
Todd Tucker Makeup Department Head
Nancy O'Dell Nancy O'Dell
Gaston Morrison New York Taxi Driver
Bill Boes Production Design
Sabrina Plisco Associate Producer, Editor
Andrea Kenyon Casting
Raphaël Benoliel Co-Producer
Jordan Kerner Producer
Marie-Soleil Dénommé Set Decoration
Patrick Baby Palais Garnier Security Guard
Ezra Swerdlow Executive Producer
Sinan Saber Third Assistant Director
Mathilde Snodgrass Pregnant Model
Juliette Ménager Casting
Vanessa Matsui Mother with Camera
Juan Miguel Vadell Animation
David E. Hall Post Production Supervisor
Michele Laliberte Supervising Art Director