Brendan Gleeson Victor Doyle
Christina Ricci Vexy (voice)
Frank Welker Azrael (voice)
Alan Cumming Gutsy Smurf (voice)
Hank Azaria Gargamel
Neil Patrick Harris Patrick Winslow
Sinan Saber Third Assistant Director
Jacob Tremblay Blue Winslow
Fred Armisen Brainy Smurf (voice)
Raphaël Benoliel Co-Producer
Michael Parks Animation
Sean Dwyer First Assistant Director
Sean Kenin Smurf Voice #1 (voice)
Adam Wylie Panicky Smurf (voice)
Katy Perry Smurfette (voice)
Jayma Mays Grace Winslow
George López Grouchy Smurf (voice)
Mario López Social Smurf (voice)
Jimmy Kimmel Passive-Aggressive Smurf (voice)
Rita Ryack Costume Design
Mylène Dinh-Robic Hotel Assistant Manager
JB Smoove Hackus (voice)
Kenan Thompson Greedy Smurf (voice)
B. J. Novak Baker Smurf (voice)
Patrick Sabongui Candy Man
Patricia Summersett Smurf Voice #2 (voice)
Becky G Songs
Joel McCrary Farmer Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Randi Wells Casting
Ezra Swerdlow Executive Producer
G.A. Aguilar Second Unit Director, Stunt Coordinator
Juliette Ménager Casting
Alain Moussi Stunts
Raja Gosnell Director
Shaquille O'Neal Smooth Smurf (voice)
Gary Basaraba Hefty Smurf (voice)
John Oliver Vanity Smurf (voice)
Paul Reubens Jokey Smurf (voice)
John Kassir Crazy Smurf (voice)
Martin Doepner Additional Third Assistant Director
Beatrice Rosen Pregnant Model
Andrea Kenyon Casting
Tom Kane Narrator Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Mathilde Snodgrass Pregnant Model
Maricel Pagulayan Associate Producer
Heitor Pereira Original Music Composer
Carolina Bartczak Peanut Mom
Nancy Honeycutt Production Supervisor
Gaston Morrison New York Taxi Driver
Phil Meheux Director of Photography
Shaun White Clueless Smurf (voice)
Jonathan Winters Papa Smurf (voice)
Karim Babin Room Service Waiter
Nancy O'Dell Nancy O'Dell
Marie-Soleil Dénommé Set Decoration
Ruth Chiang Single Mom
Karey Kirkpatrick Screenplay
Silver Butler Second Second Assistant Director
Vincent Gingras-Liberali Art Direction
Benita Allen Co-Producer, First Assistant Director
Todd Tucker Makeup Department Head
David N. Weiss Screenplay, Story
Maxence Paris Crowd Assistant Director
J. David Stem Story, Screenplay
Vanessa Matsui Mother with Camera
Bill Boes Production Design
Peyo Characters, Comic Book
David E. Hall Post Production Supervisor
Erika Rosenbaum Pregnant Mom
Dusan Dukic Curious Dad