Christina Ricci Vexy (voice)
Brendan Gleeson Victor Doyle
Neil Patrick Harris Patrick Winslow
Alan Cumming Gutsy Smurf (voice)
George López Grouchy Smurf (voice)
Hank Azaria Gargamel
Jacob Tremblay Blue Winslow
Fred Armisen Brainy Smurf (voice)
Katy Perry Smurfette (voice)
Frank Welker Azrael (voice)
Kenan Thompson Greedy Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Jayma Mays Grace Winslow
Paul Reubens Jokey Smurf (voice)
Patrick Sabongui Candy Man
JB Smoove Hackus (voice)
B.J. Novak Baker Smurf (voice)
Shaquille O'Neal Smooth Smurf (voice)
Mario López Social Smurf (voice)
John Oliver Vanity Smurf (voice)
Gary Basaraba Hefty Smurf (voice)
John Kassir Crazy Smurf (voice)
Tom Kane Narrator Smurf (voice)
Becky G Songs
Jimmy Kimmel Passive-Aggressive Smurf (voice)
Raja Gosnell Director
Adam Wylie Panicky Smurf (voice)
Joel McCrary Farmer Smurf (voice)
Mylène Dinh-Robic Hotel Assistant Manager
Shaun White Clueless Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Karey Kirkpatrick Screenplay
J. David Stem Story, Screenplay
Alain Moussi Stunts
James A. Woods Peanut Father
Jay Scherick Screenplay, Story
Carolina Bartczak Peanut Mom
Erika Rosenbaum Pregnant Mom
Beatrice Rosen Pregnant Model
Patricia Summersett Smurf Voice #2 (voice)
David N. Weiss Screenplay, Story
David Ronn Screenplay, Story
Peyo Characters, Comic Book
G.A. Aguilar Second Unit Director, Stunt Coordinator
Heitor Pereira Original Music Composer
Randi Wells Casting
Ruth Chiang Single Mom
Michael Parks Animation
Jonathan Winters Papa Smurf (voice)
Dusan Dukic Curious Dad
David Rubin Casting
Martin Doepner Additional Third Assistant Director
Andrea Kenyon Casting
Nancy O'Dell Nancy O'Dell
Gaston Morrison New York Taxi Driver
Patrick Baby Palais Garnier Security Guard
Bill Boes Production Design
Sabrina Plisco Associate Producer, Editor
Raphaël Benoliel Co-Producer
Jordan Kerner Producer
Ezra Swerdlow Executive Producer
Sinan Saber Third Assistant Director
Mathilde Snodgrass Pregnant Model
Vanessa Matsui Mother with Camera
Juan Miguel Vadell Animation
David E. Hall Post Production Supervisor
Michele Laliberte Supervising Art Director
Phil Meheux Director of Photography
Todd Tucker Makeup Department Head
Juliette Ménager Casting
Sean Kenin Smurf Voice #1 (voice)
Vincent Gingras-Liberali Art Direction