Oscar Isaac Miguel O'Hara (voice)
Daniel Kaluuya Hobie Brown (voice)
J.K. Simmons J. Jonah Jameson (voice)
Hailee Steinfeld Gwen Stacy (voice)
Andy Samberg Ben Reilly (voice)
Mahershala Ali Uncle Aaron (voice)
Jason Schwartzman Spot (voice)
Jack Quaid Peter Parker (voice)
Kathryn Hahn Doc Ock (voice)
Elizabeth Perkins May / Quippy Spider-Person (voice)
Shea Whigham George Stacy (voice)
Craig Kellman Thanks
Greta Lee LYLA (voice)
Jake Johnson Peter B. Parker (voice)
Amandla Stenberg Margo Kess: Spider-Byte (voice)
Donald Glover Aaron Davis
Issa Rae Jessica Drew (voice)
Matthew McDonald Lighting Artist, Compositing Artist
Doug Nicholas Additional Voices (voice)
Rachel Dratch Ms. Weber (voice)
Josh Keaton Spectacular Spider-Man (voice)
Kemp Powers Director
Sofia Barclay Malala Windsor: Spider-UK (voice)
Peter Sohn Ganke (voice)
Robert Getty Dialogue Editor, ADR Editor
Alan Hawkins Head of Animation
Chris Mitchell Story Artist
Yuri Lowenthal Insomniac Spider-Man (voice)
David Michie Additional Voices (voice)
Colin Lechner Foley Supervisor
Nic Novicki Lego Spider-Man (voice)
Mark Ackland Story Artist
Taran Killam Web-Slinger (voice)
Peggy Lu Mrs. Chen (uncredited)
Rez Kempton Additional Voices (voice)
Tian Chen Animation
Juan Pacheco Additional Voices (voice)
Arthur Ortiz Additional Voices (voice)
Michelle Ruff Additional Voices (voice)
Ashley London Additional Voices (voice)
Mike Rianda Additional Voices (voice), Production Consultant
Natalia Castellanos Additional Voices (voice)
Ziggy Marley Lenny (voice)
Luna Lauren Vélez Rio Morales (voice)
Phil Lord Additional Voices (voice), Writer, Producer
Karan Soni Pavitr Prabhakar (voice)
Oscar Camacho Additional Voices (voice)
Avi Arad Producer
Bruce Tanis Sound Effects Editor
Juan Pope Additional Voices (voice)
Bob Persichetti Executive Producer
Hethe Srodawa Visual Development
Laide Agunbiade Lighting Artist, Compositing Artist
Arthur D. Noda Other
Hasan Minhaj Thanks
Michael Lasker Visual Effects Supervisor
Ben Pronsky Additional Voices (voice)
Christopher Miller Additional Voices (voice), Writer, Producer
Brian Tyree Henry Jeff Morales (voice)
Amy Pascal Producer
Warren Sroka Additional Voices (voice)
Omar Smith Character Designer
Jorma Taccone Adriano Tumino / '67 (voice)
Gerard Manresa Ortega Animation
Jharrel Jerome Miles G. Morales (voice)
Atsuko Okatsuka Yuri (voice)
Justin K. Thompson Director
Joaquim Dos Santos Director
Luisa Leschin Additional Voices (voice)
Kimiko Glenn Peni Parker (voice) (uncredited)
Amanda Troop Additional Voices (voice)
Christina Steinberg Producer