Brad Pitt Vanisher
Morena Baccarin Vanessa
Matt Damon Redneck #2
Ryan Reynolds Wade Wilson / Deadpool / Juggernaut (voice), Writer, Producer
Zazie Beetz Domino
Josh Brolin Cable
Nicholas Hoult Hank McCoy / Beast (uncredited)
Bill Skarsgård Zeitgeist
James McAvoy Charles Xavier / Professor X (uncredited)
Alan Tudyk Luke - Redneck #1
Terry Crews Bedlam
Eddie Marsan Headmaster
T.J. Miller Weasel
Alexandra Shipp Ororo Monroe / Storm (uncredited)
Tye Sheridan Scott Summers / Cyclops (uncredited)
Julian Dennison Firefist