Alfred Molina Doc Ock / Otto Octavius
J.K. Simmons J. Jonah Jameson
Kirsten Dunst Mary Jane Watson
Elizabeth Banks Miss Brant
Tobey Maguire Spider-Man / Peter Parker
James Franco Harry Osborn
Willem Dafoe Green Goblin / Norman Osborn
Brianna Brown Train Passenger
Emily Deschanel Receptionist
Joel McHale Mr. Jacks
Daniel Dae Kim Raymond
Stan Lee Man Dodging Debris, Executive Producer, Comic Book
Sam Raimi Director, University Student with Bag (uncredited)
Joseph M. Caracciolo Executive Producer, Priest at Mary Jane's Wedding (uncredited)
Timothy Patrick Quill Train Passenger
Marc John Jefferies Amazed Kid
Bruce Campbell Snooty Usher
Rosemary Harris May Parker
Chris O'Hara Stunts
Kevin Feige Executive Producer
Reed Diamond 'Algernon'
Dylan Baker Dr. Curt Connors
Cosmas A. Demetriou Assistant Art Director
Douglas J. Schulman Sound Mixer
Kelvin R. Trahan Hair Department Head
Daniel Gillies John Jameson
Patricia M. Peters Screaming Nurse
Chad Stahelski Stunts
Joy Bryant Woman at Web
Paul N.J. Ottosson Supervising Sound Editor, Sound Designer
Cliff Robertson Ben Parker
John Landis Doctor
Elya Baskin Mr. Ditkovitch
Chris John Jones Creative Director
Jan O'Connell Art Department Coordinator
Kelly R. Borisy Key Grip
Michael V. Nicolo Casting Associate
Vanessa Ferlito Louise
Danny Elfman Original Music Composer
C. Scott Baker Set Designer
Phil LaMarr Train Passenger (uncredited)
Joseph V. Cicio Camera Operator
Joanne Baron Skeptical Scientist
Brent Briscoe Garbage Man
Steve Ditko Comic Book
Mary Jo 'MJ' McGrath Wardrobe Supervisor
Donna Murphy Rosalie Octavius
Bill Abbott Music Editor
Bill Nunn Joseph 'Robbie' Robertson
Alvin Sargent Screenplay
Ted Raimi Hoffman
Mageina Tovah Ursula
Aasif Mandvi Mr. Aziz
Miles Millar Screenstory
Peter McRobbie OsCorp Representative
David J. Grant Production Supervisor
Mo Henry Negative Cutter
Kevin O'Connell Sound Re-Recording Mixer
Alfred Gough Screenstory
Molly Cheek Society Woman
Louis Lombardi Poker Player
Joseph S. Alfieri Construction Coordinator
Brendan Patrick Connor Theater Traffic Cop
Scott G.G. Haller Sound Editor
J. Bryan Holloway Sculptor
Grant Curtis Hot Dog Vendor (uncredited), Co-Producer
Dion Lam Fight Choreographer
Joey Diaz Train Passenger
Doug Harlocker Property Master
Jill Brown Stunts
Christopher Flick Foley Supervisor
Bonnie Somerville Screaming Woman (uncredited)