Kirsten Dunst Mary Jane Watson
Willem Dafoe Green Goblin / Norman Osborn
J.K. Simmons J. Jonah Jameson
Ted Raimi Hoffman
Alfred Molina Doc Ock / Otto Octavius
James Franco Harry Osborn
Dylan Baker Dr. Curt Connors
Ilya Baskin Mr. Ditkovitch
Tobey Maguire Spider-Man / Peter Parker
Molly Cheek Society Woman
Stan Lee Executive Producer, Man Dodging Debris, Comic Book
Elizabeth Banks Miss Brant
Emily Deschanel Receptionist
Dion Lam Fight Choreographer
Brianna Brown Train Passenger
Peyton List Little Girl Playing on Steps (uncredited)
Brent Briscoe Garbage Man
Mageina Tovah Ursula
Christine Estabrook Mrs. Jameson
Daniel Gillies John Jameson
Bruce Campbell Snooty Usher
Joel McHale Mr. Jacks
Daniel Dae Kim Raymond
Tricia Linklater First Assistant Sound Editor
John Landis Doctor
Timothy Patrick Quill Train Passenger
Dan Hicks Train Passenger
Hank Amos Utility Stunts, Stunts
Sam Raimi Director, University Student with Bag (uncredited)
Heather Sharpe Production Office Assistant
Dennis Sands Scoring Mixer
James Acheson Costume Design
Jeff Knipp Art Direction
Donna Murphy Rosalie Octavius
François Audouy Graphic Designer
Cliff Robertson Ben Parker
Adam Austin Set Dresser
Anthony Harris Digital Color Timer
H. Barclay Aaris Special Effects Technician
Kevin Feige Executive Producer
Frank Bonsangue Pizza Man (uncredited)
Danny Elfman Original Music Composer
Vanessa Ferlito Louise
Joseph M. Caracciolo Jr. Executive Producer
Joey Diaz Train Passenger
Reed Diamond 'Algernon'
Jason Hamer Special Effects
Garrett Warren Bearded Doctor (uncredited)
Joy Bryant Woman at Web
Bonnie Somerville Screaming Woman (uncredited)
Chris O'Hara Stunts
John Paxton Houseman
Matt Blades Grip
Louis Lombardi Poker Player
Kirk Bloomberg Additional Second Assistant Camera
Chad Stahelski Stunts
Jody Fedele Visual Effects Editor
Anne Betancourt Woman at Fire
Michael Chabon Screenstory
Phil LaMarr Train Passenger (uncredited)
Marc John Jefferies Amazed Kid
Doug Harlocker Property Master
Joanne Baron Skeptical Scientist
Peter McRobbie OsCorp Representative
Dan Bradley Stunt Coordinator, Second Unit Director
Avi Arad Producer
Eran Barnea Visual Effects
Rosemary Harris May Parker
John Cameron Man Buying 'Spider-Man No More' Newspaper (uncredited)
Aasif Mandvi Mr. Aziz
Alfred Gough Screenstory
Nour Dardari Production Controller