Kirsten Dunst Mary Jane Watson
Willem Dafoe Green Goblin / Norman Osborn
J.K. Simmons J. Jonah Jameson
Tobey Maguire Spider-Man / Peter Parker
James Franco Harry Osborn
Octavia Spencer Check-In Girl
Sam Raimi Director, Popcorn Thrower (uncredited)
Elizabeth Banks Miss Brant
Lucy Lawless Punk Rock Girl
Stan Lee Comic Book, Man in Fair (uncredited), Executive Producer
Bill Hader Production Assistant
Bruce Campbell Ring Announcer
Kevin Feige Production Executive
Joe Manganiello Flash Thompson
Cliff Robertson Ben Parker
Benny Urquidez Mugger (uncredited)
Rosemary Harris May Parker
Danny Elfman Original Music Composer
David Koepp Screenplay
Sara Ramirez Cop at Carjacking
Steve Ditko Comic Book
Francine Maisler Casting
Larry Joshua Wrestling Promoter
Ted Raimi Hoffman
Scott Spiegel Marine Cop
Gerry Becker Maximilian Fargas
Laura Albert Stunts
Tony Ching Siu-Tung Stunt Coordinator
Michael Papajohn Carjacker
Stanley Anderson General Slocum
Una Damon Lab Tour Guide (uncredited)
Brad Grunberg Heckler
Craig 'Radio Man' Castaldo Man with Bike (uncredited)
Joseph D'Onofrio Opinionated Cop
Jim Ward Project Coordinator
Andray Johnson Balkan's Aide (uncredited)
Deborah Wakeham Billy's Mom
Jack Betts Henry Balkan
Jayce Bartok Subway Guitarist
Spice Williams-Crosby Stunts
Al Goto Stunts, Cop (uncredited)
Timothy Patrick Quill Wrestling Arena Guard
Bill Nunn Joseph 'Robbie' Robertson
Macy Gray Macy Gray
Bill Calvert Fireman
K.K. Dodds Simkins
Avi Arad Executive Producer
Alec Gillis Makeup Designer
Lisa Hoyle Stunts
Ron Perkins Dr. Mendel Stromm
Randy Poffo Bone Saw McGraw
Myk Watford Cop at Fire
Scott Stokdyk Visual Effects Supervisor
Tim DeZarn Philip Watson
Brian J. Williams Young Thug #2 (uncredited)
Peter Appel Cabbie
Jim Passon Color Timer
Jill Sayre Nurse
Rick Avery Cop (uncredited), Stunts
Jim Norton Surly Truck Driver
Kevin O'Connell Sound Re-Recording Mixer
John Frazier Special Effects Supervisor
Sylva Kelegian Mother at Fire
Mike Smith Stunts
Peter Gleaves ADR Mixer
Ajay Mehta Cabbie
Chris Coppola Kyle (uncredited)
Kristen Marie Holly Young Lady at Fire
Martin Pfefferkorn Thug on 8x10 (uncredited)
Ray McIntyre Jr. Visual Effects Supervisor
Don Burgess Director of Photography
Taylor Gilbert Madeline Watson