James Marsden Tim Templeton (voice)
Jeff Goldblum Dr. Armstrong (voice)
Lisa Kudrow Janice Templeton (voice)
Ariana Greenblatt Tabitha Templeton (voice)
Alec Baldwin Theodore Templeton (voice)
Eva Longoria Carol Templeton (voice)
Hans Zimmer Original Music Composer
Amy Sedaris Tina Templeton (voice)
Raphael Alejandro Nathan / Lead Baby Ninja (voice)
Tom McGrath Director, Story, Dr. Tiffany Hamilton (voice)
Jimmy Kimmel Ted Templeton (voice)
Walt Dohrn Baby Bouncer (voice)
Miles Bakshi Young Tim Voice-Over (voice)
David P. Smith Movie Patron (voice)
Michael McCullers Writer, Story, Characters
Carl Roberts Foley Recordist
David Soren Jimbo (voice)
Christi Soper Hilt Casting
Raymond Zibach Production Design
James Ryan Story Bear (Connie) (voice)
Beau Borders Sound Re-Recording Mixer
Steve Mazzaro Original Music Composer
Serenity Reign Brown Meghan (voice)
Nicholas Gist The Triplets (voice)
April Lawrence Acorn Center Computer (voice)
Reyn Doi Box Kid (voice)
James McGrath Wizzie (voice)
Paul N.J. Ottosson Sound Designer, Supervising Sound Editor
Michael J. Broomberg Foley Artist
Jeff Hermann Producer
Pedro Eustache Musician
Dave Needham Glue Baby (voice)
James Morioka Dialogue Editor
Mary Blee Editor
Matt Yocum Sound Effects Editor
Collin Erker Time Out Kid (voice)
Mark A. Hester Editor
Marla Frazee Producer, Novel
Luke Schwarzweller Sound Mix Technician
Nelson Yokota Storyboard Artist
Andrew Harkins Animation
Ashlyn Lundahl 'No' Girl (voice)
Prashanth Cavale Animation
Lisa Curtis Saunders Pipeline Technical Director
Andy Schuhler Art Direction
Angelo Raguso Sound Mixer
Christopher Gonzalez Animation
Christian Schaanning Sound Effects Editor
Christopher Brock Art Direction
John Swanson Associate Producer
Jon Eric Schmidt Associate Producer
Marjorie Cohn Pageant Mom 2 (voice)
Stephen Wood Special Effects
Nova Reed Little Bo Peep Baby (voice)
Molly K. Gray Creepy Girl (voice)
Connor Albrecht Dreidel Kid (voice)
Kristin Lowe Pageant Mom 1 (voice)