James Marsden Tim Templeton (voice)
Alec Baldwin Theodore Templeton (voice)
Eva Longoria Carol Templeton (voice)
Jeff Goldblum Dr. Armstrong (voice)
Amy Sedaris Tina Templeton (voice)
Lisa Kudrow Janice Templeton (voice)
Hans Zimmer Original Music Composer
Ariana Greenblatt Tabitha Templeton (voice)
Christi Soper Hilt Casting
Lisa Curtis Saunders Pipeline Technical Director
Michael J. Broomberg Foley Artist
Paul N.J. Ottosson Sound Designer, Supervising Sound Editor
Jimmy Kimmel Ted Templeton (voice)
Raphael Alejandro Nathan / Lead Baby Ninja (voice)
Mark A. Hester Editor
Tom McGrath Director, Story, Dr. Tiffany Hamilton (voice)
Walt Dohrn Baby Bouncer (voice)
David P. Smith Movie Patron (voice)
Steve Mazzaro Original Music Composer
David Soren Jimbo (voice)
James Ryan Story Bear (Connie) (voice)
Michael McCullers Writer, Story, Characters
James Morioka Dialogue Editor
Reyn Doi Box Kid (voice)
Pedro Eustache Musician
Prashanth Cavale Animation
Matt Yocum Sound Effects Editor
Andy Schuhler Art Direction
Beau Borders Sound Re-Recording Mixer
Miles Bakshi Young Tim Voice-Over (voice)
Andrew Harkins Animation
Mary Blee Editor
James McGrath Wizzie (voice)
Jeff Hermann Producer
April Lawrence Acorn Center Computer (voice)
John Swanson Associate Producer
Christopher Gonzalez Animation
Nelson Yokota Storyboard Artist
Marla Frazee Producer, Novel
Dave Needham Glue Baby (voice)
Serenity Reign Brown Meghan (voice)
Raymond Zibach Production Design
Christian Schaanning Sound Effects Editor
Carl Roberts Foley Recordist
Ashlyn Lundahl 'No' Girl (voice)
Luke Schwarzweller Sound Mix Technician
Stephen Wood Special Effects
Nicholas Gist The Triplets (voice)
Nova Reed Little Bo Peep Baby (voice)
Christopher Brock Art Direction
Marjorie Cohn Pageant Mom 2 (voice)
Collin Erker Time Out Kid (voice)
Molly K. Gray Creepy Girl (voice)
Kristin Lowe Pageant Mom 1 (voice)
Jon Eric Schmidt Associate Producer
Connor Albrecht Dreidel Kid (voice)
Angelo Raguso Sound Mixer