Tom Holland Jip (voice)
Robert Downey Jr. Dr. John Dolittle
Rami Malek Chee-Chee (voice)
John Cena Yoshi (voice)
Ralph Fiennes Barry (voice)
Antonio Banderas King Rassouli
Marion Cotillard Tutu (voice)
Emma Thompson Poly (voice)
Selena Gomez Betsy (voice)
Jessie Buckley Queen Victoria
Octavia Spencer Dab-Dab (voice)
Jason Mantzoukas James the Dragonfly (voice)
Michael Sheen Dr. Blair Müdfly
Jim Broadbent Lord Thomas Badgley
Will Arnett Rabbit (voice) (uncredited)
Kumail Nanjiani Plimpton (voice)
Ralph Ineson Arnall Stubbins
Craig Robinson Kevin (voice)
Harry Collett Tommy Stubbins
Danny Elfman Original Music Composer
Lucy Bevan Casting
Frances de la Tour Dragon (voice)
Scott Menville Army Ant (voice)
Matthew Stirling Stunts
Stephen Gaghan Screenplay, Director
Kasia Smutniak Lily Dolittle
Kelly Stables Mouse (voice)
Samson Kayo Pirate
Dan Gregor Screenplay
Oliver Chris Sir Gareth
Joanna Page Bethan Stubbins
Clive Francis Archbishop
Hugh Lofting Characters, Character Designer
Matt King Clyde
Jenny Beavan Costume Design
Lee Sandales Set Decoration
Susan Downey Producer
Peter Field Camera Operator
Mark Umbers Lieutenant
Russell Balogh Stunt Double, Stunts
Chris Munro Production Sound Mixer
John Mathieson Additional Director of Photography
Zoe Tahir Hairstylist
John Dykstra Visual Effects Supervisor
Carmel Laniado Lady Rose
Al Nelson Sound Designer
Levan Doran Stunts
Sarah Young Assistant Costume Designer
Frazer Fennell-Ball Second Assistant Director
Doug Mand Screenplay
Martin Pemberton Stunts, Postman
Guillermo Navarro Director of Photography
Dominic Tuohy Special Effects Supervisor
Nick Roberts ADR Mixer
Stewart Scudamore Pirate
Joe Roth Producer
Chris Lyons Special Effects Makeup Artist
Benjamin A. Burtt Sound Effects Editor
Joseph Balderrama Prisoner
Jon Taylor Sound Re-Recording Mixer
Chris Pollard Stunts
Nick Fisher Mini the Sugar Glider (voice)
Joe Kennard Stunts
Simon Crane Stunt Coordinator, Second Unit Director
Rachelle Beinart Stunt Double
Tilly Powell Stunts
Brian Nickels Stunts
Jon Mone Executive Producer
Chris Lebenzon Editor
Erol Mehmet Stunts
Ronni Brown Foley Artist
Elliot Barnes-Worrell Captain William Derrick