Emma Thompson Poly (voice)
Tom Holland Jip (voice)
Robert Downey Jr. Dr. John Dolittle
Antonio Banderas King Rassouli
Ralph Fiennes Barry (voice)
Rami Malek Chee-Chee (voice)
John Cena Yoshi (voice)
Marion Cotillard Tutu (voice)
Jessie Buckley Queen Victoria
Kumail Nanjiani Plimpton (voice)
Selena Gomez Betsy (voice)
Frances de la Tour Dragon (voice)
Luke Dunn Gielmuda Foley Supervisor
Ralph Ineson Arnall Stubbins
Alexander T.H. Browne VFX Artist
Jason Mantzoukas James the Dragonfly (voice)
Octavia Spencer Dab-Dab (voice)
Scott Menville Army Ant (voice)
Will Arnett Rabbit (voice) (uncredited)
Jim Broadbent Lord Thomas Badgley
Craig Robinson Kevin (voice)
Benjamin A. Burtt Sound Effects Editor
Dave Hamilton-Green "B" Camera Operator
Michael Sheen Dr. Blair Müdfly
Lyndon S. Hellewell Stunts
Mens-Sana Tamakloe Stunts
J.R. Grubbs Supervising Sound Editor
Mark Aaron Wagner Stunts
Oliver Chris Sir Gareth
Joe Roth Producer
Peter Hayley-Barker Grip
William M. Connor First Assistant Director, Co-Producer
Heiko von Drengenberg Storyboard Artist
Stephen W. Schriver Stunt Double
Danny Elfman Original Music Composer
Kasia Smutniak Lily Dolittle
Kelly Stables Mouse (voice)
Daniel Hoffmann-Gill Prisoner
Harry Collett Tommy Stubbins
George Kirby Stunts
Sarah Lochlan Stunts
Matt Sherren Stunts
Clive Francis Archbishop
Bill Abbott Music Editor
Christophe St-Pierre Paradis Animation Supervisor
Stephen Gaghan Screenplay, Director
Chris Lyons Special Effects Makeup Artist
Usha Chaman Construction Coordinator
Elliot Barnes-Worrell Captain William Derrick
Eugenio Alonso Yenes Stunts
Chris Munro Production Sound Mixer
Susan Downey Producer
Samson Kayo Pirate
Marlon Beyer Rieger Third Assistant Director
Matt King Clyde
Joseph Balderrama Prisoner
Jana Vance Foley Artist
Matthew Stirling Stunts
Fraser Fennell-Ball Second Assistant Director
Stewart Scudamore Pirate
Lucy Bevan Casting
Daniel Awde Stunts
Simon Crane Stunt Coordinator, Second Unit Director
Daniel Laurie Supervising Sound Editor
Frank A. Montaño Sound Re-Recording Mixer
Jon Taylor Sound Re-Recording Mixer
Joanna Page Bethan Stubbins
Mark Umbers Lieutenant
Ronni Brown Foley Artist
Fraser Taggart Second Unit Director of Photography
Carmel Laniado Lady Rose
Jenny Beavan Costume Design