Jessie Buckley Queen Victoria
Emma Thompson Poly (voice)
Robert Downey Jr. Dr. John Dolittle
Tom Holland Jip (voice)
Antonio Banderas King Rassouli
Ralph Fiennes Barry (voice)
Rami Malek Chee-Chee (voice)
John Cena Yoshi (voice)
Jim Broadbent Lord Thomas Badgley
Octavia Spencer Dab-Dab (voice)
Jason Mantzoukas James the Dragonfly (voice)
Selena Gomez Betsy (voice)
Will Arnett Rabbit (voice) (uncredited)
Marion Cotillard Tutu (voice)
Kumail Nanjiani Plimpton (voice)
Frances de la Tour Dragon (voice)
Ralph Ineson Arnall Stubbins
Michael Sheen Dr. Blair Müdfly
Sid Sagar Jeff the Prisoner
Kasia Smutniak Lily Dolittle
Craig Robinson Kevin (voice)
Bill Abbott Music Editor
Clive Francis Archbishop
Stewart Scudamore Pirate
Rob Cooper Stunts
Joanna Page Bethan Stubbins
Mark Umbers Lieutenant
Benjamin Ashley Stunts
Harry Collett Tommy Stubbins
Scott Menville Army Ant (voice)
Martin Pemberton Postman, Stunts
Edgardo Simone Orchestrator
Susan Downey Producer
Danny Elfman Original Music Composer
Nick Moore Additional Editing
Kelly Stables Mouse (voice)
Matt King Clyde
Tim Treloar Humphrey the Whale (voice)
Frank Cuomo Production Manager
Dan Gregor Screenplay
Jon Mone Executive Producer
Benos Noble Stunts
Sonny Ashbourne Serkis Arnall Stubbins Jr.
Samson Kayo Pirate
Andy Wareham Stunts
Elliot Barnes-Worrell Captain William Derrick
Chris Pollard Stunts
Matthew Stirling Stunts
Lucy Bevan Casting
Brian Nickels Stunts
Chris Lyons Special Effects Makeup Artist
Joe Roth Producer
Chris Lebenzon Editor
Russell Balogh Stunt Double, Stunts
Jenny Beavan Costume Design
Teresa Orlando Third Assistant Director
Kyrie McAlpin Baby Animal (voice)
David Lee Gaffer
Simon Crane Second Unit Director, Stunt Coordinator
Marvin Campbell Stunts
Ranjani Brow Mouse (voice)
Levan Doran Stunts
Stephen Gaghan Director, Screenplay
Jay Maidment Still Photographer
Erol Mehmet Stunts
Fraser Taggart Second Unit Director of Photography
Al Nelson Sound Designer
Lisa Rodgers Post Production Supervisor
Steve Bartek Orchestrator
Joseph Balderrama Prisoner
Katy Bullock Stunts
Ronni Brown Foley Artist