Tom Holland Jip (voice)
Robert Downey Jr. Dr. John Dolittle
John Cena Yoshi (voice)
Rami Malek Chee-Chee (voice)
Ralph Fiennes Barry (voice)
Emma Thompson Poly (voice)
Octavia Spencer Dab-Dab (voice)
Selena Gomez Betsy (voice)
Antonio Banderas King Rassouli
Marion Cotillard Tutu (voice)
Jessie Buckley Queen Victoria
Michael Sheen Dr. Blair Müdfly
Kumail Nanjiani Plimpton (voice)
Jason Mantzoukas James the Dragonfly (voice)
Ralph Ineson Arnall Stubbins
Craig Robinson Kevin (voice)
Will Arnett Rabbit (voice) (uncredited)
Jim Broadbent Lord Thomas Badgley
Scott Menville Army Ant (voice)
Kelly Stables Mouse (voice)
Harry Collett Tommy Stubbins
Danny Elfman Original Music Composer
Frances de la Tour Dragon (voice)
Mark Umbers Lieutenant
Kasia Smutniak Lily Dolittle
Clive Francis Archbishop
Stephen Gaghan Screenplay, Director
Carmel Laniado Lady Rose
Joanna Page Bethan Stubbins
Oliver Chris Sir Gareth
Matt King Clyde
Simon Crane Stunt Coordinator, Second Unit Director
Stewart Scudamore Pirate
Joseph Balderrama Prisoner
Rachelle Beinart Stunt Double
Sonny Ashbourne Serkis Arnall Stubbins Jr.
Dan Gregor Screenplay
Daniel Laurie Supervising Sound Editor
Al Nelson Sound Designer
Joe Roth Producer
Susan Downey Producer
Jenny Beavan Costume Design
Lucy Bevan Casting
Jon Taylor Sound Re-Recording Mixer
Fraser Taggart Second Unit Director of Photography
Chris Lyons Special Effects Makeup Artist
Lisa Rodgers Post Production Supervisor
Levan Doran Stunts
Chris Lebenzon Editor
Samson Kayo Pirate
Frank A. Montaño Sound Re-Recording Mixer
Matthew Stirling Stunts
Guillermo Navarro Director of Photography
Jeff Kirschenbaum Producer
Hugh Lofting Characters, Character Designer
Andy Wareham Stunts
Elliot Barnes-Worrell Captain William Derrick
George Kirby Stunts
Erol Mehmet Stunts
John-Luke Roberts Pirate / Animal Performer
John Dykstra Visual Effects Supervisor
Doug Mand Screenplay
Dominic Tuohy Special Effects Supervisor
Matthew Gray Supervising Art Director
Bogdan Kumšackij Stunts
Bill Abbott Music Editor
Russell Balogh Stunt Double, Stunts
David Lee Gaffer
Peter Field Camera Operator
Lee Sandales Set Decoration
Sarah Lochlan Stunts
Brian Nickels Stunts