Tom Holland Jip (voice)
Robert Downey Jr. Dr. John Dolittle
Rami Malek Chee-Chee (voice)
Ralph Fiennes Barry (voice)
Antonio Banderas King Rassouli
John Cena Yoshi (voice)
Marion Cotillard Tutu (voice)
Jessie Buckley Queen Victoria
Selena Gomez Betsy (voice)
Emma Thompson Poly (voice)
Michael Sheen Dr. Blair Müdfly
Octavia Spencer Dab-Dab (voice)
Jim Broadbent Lord Thomas Badgley
Will Arnett Rabbit (voice) (uncredited)
Jason Mantzoukas James the Dragonfly (voice)
Kumail Nanjiani Plimpton (voice)
Ralph Ineson Arnall Stubbins
Craig Robinson Kevin (voice)
Lucy Bevan Casting
Harry Collett Tommy Stubbins
Danny Elfman Original Music Composer
Frances de la Tour Dragon (voice)
Kelly Stables Mouse (voice)
Scott Menville Army Ant (voice)
Joanna Page Bethan Stubbins
Samson Kayo Pirate
Matthew Stirling Stunts
Kasia Smutniak Lily Dolittle
Stephen Gaghan Screenplay, Director
Oliver Chris Sir Gareth
Clive Francis Archbishop
Peter Field Camera Operator
Dan Gregor Screenplay
Matt King Clyde
Jenny Beavan Costume Design
Susan Downey Producer
Hugh Lofting Characters, Character Designer
Carmel Laniado Lady Rose
Al Nelson Sound Designer
Lee Sandales Set Decoration
John Dykstra Visual Effects Supervisor
John Mathieson Additional Director of Photography
Guillermo Navarro Director of Photography
Mark Umbers Lieutenant
Chris Munro Production Sound Mixer
Sarah Young Assistant Costume Designer
Joseph Balderrama Prisoner
Zoe Tahir Hairstylist
Stewart Scudamore Pirate
Nick Roberts ADR Mixer
Joe Kennard Stunts
Joe Roth Producer
Nick Fisher Mini the Sugar Glider (voice)
Tilly Powell Stunts
David Cheesman Property Master
Chris Lyons Special Effects Makeup Artist
Benjamin A. Burtt Sound Effects Editor
Martin Pemberton Stunts, Postman
Frazer Fennell-Ball Second Assistant Director
Levan Doran Stunts
Brian Nickels Stunts
Elliot Barnes-Worrell Captain William Derrick
Frank A. Montaño Sound Re-Recording Mixer
Erol Mehmet Stunts
Chris Pollard Stunts
Dominic Tuohy Special Effects Supervisor
Fraser Taggart Second Unit Director of Photography
Simon Crane Stunt Coordinator, Second Unit Director
Shaun McKee On Set Yoshi / Animal Performer
Martin Wilde Stunts
Will Coubrough Art Direction
Steve Jehu Stunts