Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Bella Ramsey Flotsam
Rebecca Hall Dr. Grace Hart
Kelly Macdonald Mrs. Martha Hudson
Hugh Laurie Mycroft Holmes (uncredited)
Billy Zane Billy Zane
Will Ferrell Sherlock Holmes, Producer
John C. Reilly Dr. John Watson
Noah Jupe Doxy
Pam Ferris Queen Victoria
Lauren Lapkus Millie
Steve Coogan Gustav Klinger (uncredited)
Rob Brydon Inspector Lestrade
Etan Cohen Director, Writer
Adam McKay Producer
Bronson Webb Jonathan Nightingale
Kieran O'Brien PC Smalls
Michael Buffer Fight Fan #1
Arthur Conan Doyle Characters
Lilly Aspell Newschild
Chris Henchy Executive Producer
Jess Liaudin Hangman
Mark Mothersbaugh Original Music Composer
Oliver Maltman Telegraph Operator
Wolf Roth Sigmund Freud
Clayton Townsend Producer
Dean Zimmerman Editor
Michael Culkin The Judge
Jordan Long Herbert (uncredited)
Tolga Kenan Stunts, Utility Stunts
Paul Bigley Teacher #1
Jana Pérez Lestrade's Wife
Martin Bishop Priest
Martin Bassindale One Man Band (uncredited)
Lucinda Syson Casting
Billy Jenkins Mud Fog
Jason Thorpe Butler
Jorge Leon British Soldier (uncredited)
Jamie Christopher First Assistant Director
Marc Mailley Stunts
James Eeles Manager Mr. Petrucka (uncredited)
Matthew Sharp Assistant Director
Bridget Cook Hairstylist
Brooke Lyndon-Stanford Visual Effects Supervisor
Jeremy Woodhead Makeup Designer
Daniel Fearn Drooling Man Companion
Martyn Mayger Buckingham Palace Guest (uncredited)
Toby Britton Art Direction
Jo McLaren Stunt Coordinator
Gerard Monaco Titanic Ship Officer
Shawn Dixon Upper Class Gentleman #1 (uncredited)
Sue Whitaker Art Direction
David Allday Supervising Art Director
Beatrix Aruna Pasztor Costume Designer
Codie-Lei Eastick Young Watson
Joe Watts Stunts
Jessica Elbaum Executive Producer
Fraser Taggart Second Unit Director of Photography
Hector Bateman-Harden Young Sherlock Holmes
Ethan Rouse Newschild
Erik Jessen Editor
Paul Cassidy Charlie Chaplin
Stanley Eldridge Waiter
Ella Bright Bridgette
Kenneth Hadley Headmaster
Oliver Wood Director of Photography
Jordan Schur Executive Producer
Deepak Anand Nobleman (uncredited)
Belinda Hodgson Key Makeup Artist
Jen Annor Boom Operator
Karl Farrer Russian Merchant (uncredited)
James Hambidge Production Design