Will Ferrell Sherlock Holmes, Producer
Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Rebecca Hall Dr. Grace Hart
Hugh Laurie Mycroft Holmes (uncredited)
Billy Zane Billy Zane
Steve Coogan Gustav Klinger (uncredited)
John C. Reilly Dr. John Watson
Kelly Macdonald Mrs. Martha Hudson
Pam Ferris Queen Victoria
Noah Jupe Doxy
Lauren Lapkus Millie
Bella Ramsey Flotsam
Kieran O'Brien PC Smalls
Rob Brydon Inspector Lestrade
Michael Buffer Fight Fan #1
Adam McKay Producer
Etan Cohen Director, Writer
Bronson Webb Jonathan Nightingale
Billy Jenkins Mud Fog
Lilly Aspell Newschild
Arthur Conan Doyle Characters
Jordan Long Herbert (uncredited)
Martin Bishop Priest
Michael Culkin The Judge
Chris Henchy Executive Producer
Oliver Maltman Telegraph Operator
Paul Bigley Teacher #1
Jordan Schur Executive Producer
Jason Thorpe Butler
Lucinda Syson Casting
Dean Zimmerman Editor
Jess Liaudin Hangman
Ella Bright Bridgette
Jeremy Woodhead Makeup Designer
Gerard Monaco Titanic Ship Officer
Mark Mothersbaugh Original Music Composer
Wolf Roth Sigmund Freud
James Eeles Manager Mr. Petrucka (uncredited)
Karl Farrer Russian Merchant (uncredited)
Jorge Leon British Soldier (uncredited)
Fraser Taggart Second Unit Director of Photography
Bridget Cook Hairstylist
Martin Bassindale One Man Band (uncredited)
Marc Mailley Stunts
Brooke Lyndon-Stanford Visual Effects Supervisor
James Hambidge Production Design
Beatrix Aruna Pasztor Costume Designer
Sue Whitaker Art Direction
Clayton Townsend Producer
Paul Cassidy Charlie Chaplin
Daniel Fearn Drooling Man Companion
Matthew Sharp Assistant Director
Oliver Wood Director of Photography
Nathan Osgood Mark Twain
Jimmy Miller Producer
Kenneth Hadley Headmaster
Adam Scherr Brawn
Jessica Elbaum Executive Producer
Bruce Buffer Fight Fan #2
Martyn Mayger Buckingham Palace Guest (uncredited)
Jana Pérez Lestrade's Wife
Joseph Macnab Fitness Instructor (uncredited)
Ethan Rouse Newschild
Hector Bateman-Harden Young Sherlock Holmes
Toby Britton Art Direction
Jo McLaren Stunt Coordinator
Tolga Kenan Stunts, Utility Stunts
David Allday Supervising Art Director
Christopher Wyatt Art Direction
Matt Riley Executive Producer
Jamie Christopher First Assistant Director
Erik Jessen Editor