Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Bella Ramsey Flotsam
Hugh Laurie Mycroft Holmes (uncredited)
Will Ferrell Sherlock Holmes, Producer
Rebecca Hall Dr. Grace Hart
Kelly Macdonald Mrs. Martha Hudson
Adam Scherr Brawn
Arthur Conan Doyle Characters
Lauren Lapkus Millie
Billy Zane Billy Zane
Pam Ferris Queen Victoria
Bronson Webb Jonathan Nightingale
John C. Reilly Dr. John Watson
Adam McKay Producer
Noah Jupe Doxy
Etan Cohen Director, Writer
Steve Coogan Gustav Klinger (uncredited)
Jordan Long Herbert (uncredited)
Joe Watts Stunts
Michael Buffer Fight Fan #1
Kieran O'Brien PC Smalls
David Stoller Hudson's Guard
Joseph Macnab Fitness Instructor (uncredited)
Martin Bassindale One Man Band (uncredited)
Lucinda Syson Casting
Rob Brydon Inspector Lestrade
Kenneth Hadley Headmaster
Michael Culkin The Judge
Jimmy Miller Producer
Gerard Monaco Titanic Ship Officer
Clayton Townsend Producer
Ella Bright Bridgette
Jason Thorpe Butler
Billy Jenkins Mud Fog
Martin Bishop Priest
Karl Farrer Russian Merchant (uncredited)
Lilly Aspell Newschild
Oliver Wood Director of Photography
Fraser Taggart Second Unit Director of Photography
Nathan Osgood Mark Twain
Paul Bigley Teacher #1
Bruce Buffer Fight Fan #2
David Shackleton Albert Einstein
Wolf Roth Sigmund Freud
Chris Henchy Executive Producer
Oliver Maltman Telegraph Operator
Mark Mothersbaugh Original Music Composer
Hugh O'Brien Garden Party Guest (uncredited)
Paddy Holland Tough Kid
Dean Zimmerman Editor
Jorge Leon British Soldier (uncredited)
Jamie Christopher First Assistant Director
Jess Liaudin Hangman
James Eeles Manager Mr. Petrucka (uncredited)
Jana Pérez Lestrade's Wife
Brooke Lyndon-Stanford Visual Effects Supervisor
Craig Thomas Lambert Yeoman of the Guard (uncredited)
Jessica Elbaum Executive Producer
Erik Jessen Editor
Beatrix Aruna Pasztor Costume Designer
Niamh Coulter Set Decoration
Tolga Kenan Stunts, Utility Stunts
Daniel Fearn Drooling Man Companion
Martyn Mayger Buckingham Palace Guest (uncredited)
Matthew Sharp Assistant Director
Jeremy Woodhead Makeup Designer
Bridget Cook Hairstylist
Ethan Rouse Newschild
Marc Mailley Stunts
Christopher Wyatt Art Direction
Sara Beasley Mrs. Frobisher (uncredited)
Jo McLaren Stunt Coordinator