Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Hugh Laurie Mycroft Holmes (uncredited)
Will Ferrell Sherlock Holmes, Producer
John C. Reilly Dr. John Watson
Billy Zane Billy Zane
Rebecca Hall Dr. Grace Hart
Steve Coogan Gustav Klinger (uncredited)
Bella Ramsey Flotsam
Kelly Macdonald Mrs. Martha Hudson
Kieran O'Brien PC Smalls
Adam McKay Producer
Pam Ferris Queen Victoria
Beatrix Aruna Pasztor Costume Designer
Lauren Lapkus Millie
Arthur Conan Doyle Characters
Noah Jupe Doxy
Anthony Richard Rowe Victorian Gentleman (uncredited)
Lucinda Syson Casting
Billy Jenkins Mud Fog
Bronson Webb Jonathan Nightingale
Rob Brydon Inspector Lestrade
Etan Cohen Director, Writer
Michael Culkin The Judge
Lilly Aspell Newschild
Hugh O'Brien Garden Party Guest (uncredited)
Jordan Long Herbert (uncredited)
Chris Henchy Executive Producer
Soren Bendt Aaboe Pedersen Storyboard Artist
Michael Buffer Fight Fan #1
Jeremy Woodhead Makeup Designer
Mark Mothersbaugh Original Music Composer
Paul Bigley Teacher #1
Ella Bright Bridgette
Martin Bishop Priest
Karl Farrer Russian Merchant (uncredited)
Dean Zimmerman Editor
Gerard Monaco Titanic Ship Officer
Brooke Lyndon-Stanford Visual Effects Supervisor
Oliver Wood Director of Photography
Autumn Butler Makeup Artist
Daniel Fearn Drooling Man Companion
Wolf Roth Sigmund Freud
Jess Liaudin Hangman
Jimmy Miller Producer
Adam Scherr Brawn
Fraser Taggart Second Unit Director of Photography
Tolga Kenan Stunts, Utility Stunts
Jo McLaren Stunt Coordinator
Renata Gilbert Makeup Artist
David Allday Supervising Art Director
Kenneth Hadley Headmaster
Matthew Sharp Assistant Director
Jessica Elbaum Executive Producer
Martyn Mayger Buckingham Palace Guest (uncredited)
Marc Mailley Stunts
Clayton Townsend Producer
Belinda Hodgson Key Makeup Artist
Sue Whitaker Art Direction
George Dean Painter
Ethan Rouse Newschild
Jana Pérez Lestrade's Wife
Oliver Maltman Telegraph Operator
Jorge Leon British Soldier (uncredited)
Erik Jessen Editor
Martin Bassindale One Man Band (uncredited)
Toby Britton Art Direction
Bruce Buffer Fight Fan #2
Jason Thorpe Butler
Matt Riley Executive Producer
Deepak Anand Nobleman (uncredited)
Nadia Homri Makeup Artist
Bridget Cook Hairstylist