Will Ferrell Sherlock Holmes, Producer
Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Kelly Macdonald Mrs. Martha Hudson
Hugh Laurie Mycroft Holmes (uncredited)
John C. Reilly Dr. John Watson
Bella Ramsey Flotsam
Billy Zane Billy Zane
Lauren Lapkus Millie
Noah Jupe Doxy
Rebecca Hall Dr. Grace Hart
Pam Ferris Queen Victoria
Steve Coogan Gustav Klinger (uncredited)
Adam McKay Producer
Jessica Elbaum Executive Producer
Rob Brydon Inspector Lestrade
Lilly Aspell Newschild
Kieran O'Brien PC Smalls
Michael Buffer Fight Fan #1
Etan Cohen Director, Writer
Oliver Maltman Telegraph Operator
Arthur Conan Doyle Characters
Jordan Long Herbert (uncredited)
Bronson Webb Jonathan Nightingale
Chris Henchy Executive Producer
Jess Liaudin Hangman
Michael Culkin The Judge
Jeremy Woodhead Makeup Designer
Paul Bigley Teacher #1
Billy Jenkins Mud Fog
Dean Zimmerman Editor
Martin Bishop Priest
Mark Mothersbaugh Original Music Composer
Jason Thorpe Butler
Tolga Kenan Stunts, Utility Stunts
Fraser Taggart Second Unit Director of Photography
James Eeles Manager Mr. Petrucka (uncredited)
Jamie Christopher First Assistant Director
Lucinda Syson Casting
Martin Bassindale One Man Band (uncredited)
Jo McLaren Stunt Coordinator
Marc Mailley Stunts
Daniel Fearn Drooling Man Companion
Wolf Roth Sigmund Freud
Clayton Townsend Producer
Jorge Leon British Soldier (uncredited)
Jana Pérez Lestrade's Wife
Matthew Sharp Assistant Director
Ella Bright Bridgette
Paul Cassidy Charlie Chaplin
Gerard Monaco Titanic Ship Officer
Toby Britton Art Direction
Oliver Wood Director of Photography
Karl Farrer Russian Merchant (uncredited)
Jamie Baughan Titanic Ship Officer Liaison
Bridget Cook Hairstylist
Kenneth Hadley Headmaster
Deepak Anand Nobleman (uncredited)
Hector Bateman-Harden Young Sherlock Holmes
Bruce Buffer Fight Fan #2
Brooke Lyndon-Stanford Visual Effects Supervisor
Codie-Lei Eastick Young Watson
Jordan Schur Executive Producer
James Hambidge Production Design
Phil Hodges Mr. Algernon Barkworth (uncredited)
Nathan Osgood Mark Twain
Shawn Dixon Upper Class Gentleman #1 (uncredited)
Niamh Coulter Set Decoration
Sue Whitaker Art Direction
Belinda Hodgson Key Makeup Artist
David Allday Supervising Art Director
Beatrix Aruna Pasztor Costume Designer
Joseph Macnab Fitness Instructor (uncredited)