Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Hugh Laurie Mycroft Holmes (uncredited)
Rebecca Hall Dr. Grace Hart
Billy Zane Billy Zane
Will Ferrell Sherlock Holmes, Producer
John C. Reilly Dr. John Watson
Bella Ramsey Flotsam
Kieran O'Brien PC Smalls
Steve Coogan Gustav Klinger (uncredited)
Lauren Lapkus Millie
Kelly Macdonald Mrs. Martha Hudson
Pam Ferris Queen Victoria
Adam McKay Producer
Noah Jupe Doxy
Etan Cohen Director, Writer
Arthur Conan Doyle Characters
Rob Brydon Inspector Lestrade
Michael Culkin The Judge
Jordan Long Herbert (uncredited)
Mark Mothersbaugh Original Music Composer
Jana Pérez Lestrade's Wife
Lilly Aspell Newschild
Bronson Webb Jonathan Nightingale
Chris Henchy Executive Producer
Ella Bright Bridgette
Billy Jenkins Mud Fog
James Eeles Manager Mr. Petrucka (uncredited)
Karl Farrer Russian Merchant (uncredited)
Michael Buffer Fight Fan #1
Tolga Kenan Stunts, Utility Stunts
Jimmy Miller Producer
Brooke Lyndon-Stanford Visual Effects Supervisor
Adam Scherr Brawn
Oliver Maltman Telegraph Operator
Gerard Monaco Titanic Ship Officer
Paul Bigley Teacher #1
Ethan Rouse Newschild
Wolf Roth Sigmund Freud
Toby Britton Art Direction
Jess Liaudin Hangman
Jen Annor Boom Operator
Matt Riley Executive Producer
Jo McLaren Stunt Coordinator
Phil Hodges Mr. Algernon Barkworth (uncredited)
Shawn Dixon Upper Class Gentleman #1 (uncredited)
Paddy Holland Tough Kid
Daniel Fearn Drooling Man Companion
Matthew Sharp Assistant Director
Oliver Wood Director of Photography
Jason Thorpe Butler
Bruce Buffer Fight Fan #2
Dean Zimmerman Editor
Sue Whitaker Art Direction
Kenneth Hadley Headmaster
Marc Mailley Stunts
Jessica Elbaum Executive Producer
Paul Cassidy Charlie Chaplin
Lucinda Syson Casting
Martin Bishop Priest
Fraser Taggart Second Unit Director of Photography
Autumn Butler Makeup Artist
Robert Cawsey Waiter
Jeremy Woodhead Makeup Designer
Jamie Christopher First Assistant Director
George Dean Painter
Beatrix Aruna Pasztor Costume Designer
Jorge Leon British Soldier (uncredited)
Craig Thomas Lambert Yeoman of the Guard (uncredited)
Buddie Wilkinson Standby Property Master
David Allday Supervising Art Director
Deepak Anand Nobleman (uncredited)
Clayton Townsend Producer