Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Bella Ramsey Flotsam
Rebecca Hall Dr. Grace Hart
Kelly Macdonald Mrs. Martha Hudson
Hugh Laurie Mycroft Holmes (uncredited)
Will Ferrell Sherlock Holmes, Producer
John C. Reilly Dr. John Watson
Billy Zane Billy Zane
Noah Jupe Doxy
Pam Ferris Queen Victoria
Lauren Lapkus Millie
Steve Coogan Gustav Klinger (uncredited)
Rob Brydon Inspector Lestrade
Etan Cohen Director, Writer
Bronson Webb Jonathan Nightingale
Kieran O'Brien PC Smalls
Adam McKay Producer
Michael Buffer Fight Fan #1
Arthur Conan Doyle Characters
Lilly Aspell Newschild
Chris Henchy Executive Producer
Jess Liaudin Hangman
Oliver Maltman Telegraph Operator
Wolf Roth Sigmund Freud
Clayton Townsend Producer
Michael Culkin The Judge
Marc Mailley Stunts
Mark Mothersbaugh Original Music Composer
Jordan Long Herbert (uncredited)
Tolga Kenan Stunts, Utility Stunts
Paul Bigley Teacher #1
Jana Pérez Lestrade's Wife
Martin Bishop Priest
Billy Jenkins Mud Fog
Jason Thorpe Butler
Lucinda Syson Casting
Daniel Fearn Drooling Man Companion
Martin Bassindale One Man Band (uncredited)
Jamie Christopher First Assistant Director
Dean Zimmerman Editor
James Eeles Manager Mr. Petrucka (uncredited)
Matthew Sharp Assistant Director
Brooke Lyndon-Stanford Visual Effects Supervisor
Jeremy Woodhead Makeup Designer
Bridget Cook Hairstylist
Martyn Mayger Buckingham Palace Guest (uncredited)
Toby Britton Art Direction
Sue Whitaker Art Direction
Jo McLaren Stunt Coordinator
Fraser Taggart Second Unit Director of Photography
Gerard Monaco Titanic Ship Officer
Shawn Dixon Upper Class Gentleman #1 (uncredited)
David Allday Supervising Art Director
Jessica Elbaum Executive Producer
Codie-Lei Eastick Young Watson
Joe Watts Stunts
Ethan Rouse Newschild
Jorge Leon British Soldier (uncredited)
Hector Bateman-Harden Young Sherlock Holmes
Erik Jessen Editor
Paul Cassidy Charlie Chaplin
Stanley Eldridge Waiter
Ella Bright Bridgette
Kenneth Hadley Headmaster
Oliver Wood Director of Photography
Jordan Schur Executive Producer
Deepak Anand Nobleman (uncredited)
Belinda Hodgson Key Makeup Artist
Jen Annor Boom Operator
Jimmy Miller Producer
Beatrix Aruna Pasztor Costume Designer
Karl Farrer Russian Merchant (uncredited)