Noah Jupe Doxy
Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
John C. Reilly Dr. John Watson
Billy Zane Billy Zane
Clayton Townsend Producer
Hugh Laurie Mycroft Holmes (uncredited)
Rebecca Hall Dr. Grace Hart
Bella Ramsey Flotsam
Will Ferrell Sherlock Holmes, Producer
Kelly Macdonald Mrs. Martha Hudson
Steve Coogan Gustav Klinger (uncredited)
Kieran O'Brien PC Smalls
Lauren Lapkus Millie
Pam Ferris Queen Victoria
Gerard Monaco Titanic Ship Officer
Bronson Webb Jonathan Nightingale
Brooke Lyndon-Stanford Visual Effects Supervisor
Lilly Aspell Newschild
Jess Liaudin Hangman
Martin Bishop Priest
Adam McKay Producer
Mark Mothersbaugh Original Music Composer
Rob Brydon Inspector Lestrade
Michael Buffer Fight Fan #1
Lucinda Syson Casting
Martin Bassindale One Man Band (uncredited)
Joseph Macnab Fitness Instructor (uncredited)
Jason Thorpe Butler
Jordan Long Herbert (uncredited)
Matthew Sharp Assistant Director
Etan Cohen Director, Writer
Jeremy Woodhead Makeup Designer
Kenneth Hadley Headmaster
Michael Culkin The Judge
Lee Sharp Boom Operator
Belinda Hodgson Key Makeup Artist
Oliver Maltman Telegraph Operator
Ella Bright Bridgette
Arthur Conan Doyle Characters
Billy Jenkins Mud Fog
Paul Bigley Teacher #1
Karl Farrer Russian Merchant (uncredited)
Deepak Anand Nobleman (uncredited)
Niamh Coulter Set Decoration
Paul Cassidy Charlie Chaplin
Hector Bateman-Harden Young Sherlock Holmes
Stanley Eldridge Waiter
Toby Britton Art Direction
Oliver Wood Director of Photography
Joe Watts Stunts
Robert Cawsey Waiter
James Eeles Manager Mr. Petrucka (uncredited)
Jen Annor Boom Operator
George Dean Painter
Nathan Osgood Mark Twain
Adam Scherr Brawn
Dean Zimmerman Editor
Wolf Roth Sigmund Freud
Jo McLaren Stunt Coordinator
James Hambidge Production Design
Chris Henchy Executive Producer
Fraser Taggart Second Unit Director of Photography
Daniel Fearn Drooling Man Companion
Jorge Leon British Soldier (uncredited)
Renata Gilbert Makeup Artist
David Stoller Hudson's Guard
Marc Mailley Stunts
Sue Whitaker Art Direction
Jessica Elbaum Executive Producer
Ethan Rouse Newschild
Paddy Holland Tough Kid
Tolga Kenan Stunts, Utility Stunts