Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
John C. Reilly Dr. John Watson
Rebecca Hall Dr. Grace Hart
Billy Zane Billy Zane
Hugh Laurie Mycroft Holmes (uncredited)
Bella Ramsey Flotsam
Noah Jupe Doxy
Kelly Macdonald Mrs. Martha Hudson
Steve Coogan Gustav Klinger (uncredited)
Will Ferrell Sherlock Holmes, Producer
Bronson Webb Jonathan Nightingale
Kieran O'Brien PC Smalls
Lauren Lapkus Millie
Pam Ferris Queen Victoria
Adam McKay Producer
Lucinda Syson Casting
Etan Cohen Director, Writer
Lilly Aspell Newschild
Jess Liaudin Hangman
Rob Brydon Inspector Lestrade
Michael Buffer Fight Fan #1
Martin Bassindale One Man Band (uncredited)
Joseph Macnab Fitness Instructor (uncredited)
Jason Thorpe Butler
Brooke Lyndon-Stanford Visual Effects Supervisor
Jordan Long Herbert (uncredited)
Kenneth Hadley Headmaster
Gerard Monaco Titanic Ship Officer
Michael Culkin The Judge
Jimmy Miller Producer
Lee Sharp Boom Operator
Clayton Townsend Producer
Oliver Maltman Telegraph Operator
Ella Bright Bridgette
Arthur Conan Doyle Characters
Mark Mothersbaugh Original Music Composer
Billy Jenkins Mud Fog
Paul Bigley Teacher #1
Karl Farrer Russian Merchant (uncredited)
Martin Bishop Priest
Stanley Eldridge Waiter
Toby Britton Art Direction
Oliver Wood Director of Photography
Jo McLaren Stunt Coordinator
Fraser Taggart Second Unit Director of Photography
James Eeles Manager Mr. Petrucka (uncredited)
Nathan Osgood Mark Twain
Adam Scherr Brawn
Dean Zimmerman Editor
Wolf Roth Sigmund Freud
James Hambidge Production Design
Chris Henchy Executive Producer
Tolga Kenan Stunts, Utility Stunts
George Dean Painter
Jorge Leon British Soldier (uncredited)
Jamie Christopher First Assistant Director
David Stoller Hudson's Guard
Jeremy Woodhead Makeup Designer
Marc Mailley Stunts
Sue Whitaker Art Direction
Matthew Sharp Assistant Director
Daniel Fearn Drooling Man Companion
Ethan Rouse Newschild
Paddy Holland Tough Kid
Renata Gilbert Makeup Artist
Jana Pérez Lestrade's Wife
Craig Thomas Lambert Yeoman of the Guard (uncredited)
Autumn Butler Makeup Artist
Jessica Elbaum Executive Producer
Erik Jessen Editor
Bruce Buffer Fight Fan #2
Hector Bateman-Harden Young Sherlock Holmes