Noah Jupe Doxy
Bella Ramsey Flotsam
Hugh Laurie Mycroft Holmes (uncredited)
Ralph Fiennes Prof. James Moriarty / Jacob Musgrave
Kelly Macdonald Mrs. Martha Hudson
Rebecca Hall Dr. Grace Hart
Etan Cohen Writer, Director
John C. Reilly Dr. John Watson
Adam Scherr Brawn
Arthur Conan Doyle Characters
Lauren Lapkus Millie
Clayton Townsend Producer
Billy Zane Billy Zane
Pam Ferris Queen Victoria
Adam McKay Producer
Steve Coogan Gustav Klinger (uncredited)
Michael Buffer Fight Fan #1
Kieran O'Brien PC Smalls
Joe Watts Stunts
Will Ferrell Sherlock Holmes, Producer
Joseph Macnab Fitness Instructor (uncredited)
Bronson Webb Jonathan Nightingale
Kenneth Hadley Headmaster
Rob Brydon Inspector Lestrade
Lucinda Syson Casting
Michael Culkin The Judge
Jimmy Miller Producer
David Stoller Hudson's Guard
Daniel Fearn Drooling Man Companion
Ella Bright Bridgette
Jason Thorpe Butler
Billy Jenkins Mud Fog
Karl Farrer Russian Merchant (uncredited)
Phil Hodges Mr. Algernon Barkworth (uncredited)
Lilly Aspell Newschild
Mark Mothersbaugh Original Music Composer
Jordan Long Herbert (uncredited)
Tolga Kenan Utility Stunts, Stunts
Martin Bishop Priest
Nathan Osgood Mark Twain
Paul Bigley Teacher #1
Wolf Roth Sigmund Freud
James Eeles Manager Mr. Petrucka (uncredited)
Chris Henchy Executive Producer
Fraser Taggart Second Unit Director of Photography
Oliver Wood Director of Photography
Brooke Lyndon-Stanford Visual Effects Supervisor
Oliver Maltman Telegraph Operator
Jo McLaren Stunt Coordinator
Erik Jessen Editor
Paddy Holland Tough Kid
Martin Bassindale One Man Band (uncredited)
Sue Whitaker Art Direction
Jen Annor Boom Operator
Jess Liaudin Hangman
Marc Mailley Stunts
Jamie Christopher First Assistant Director
Jorge Leon British Soldier (uncredited)
Jana Pérez Lestrade's Wife
Craig Thomas Lambert Yeoman of the Guard (uncredited)
David Allday Supervising Art Director
Gerard Monaco Titanic Ship Officer
Christopher Wyatt Art Direction
Beatrix Aruna Pasztor Costume Designer
Dean Zimmerman Editor
Bridget Cook Hairstylist
Ethan Rouse Newschild
Matthew Sharp Assistant Director
Sara Beasley Mrs. Frobisher (uncredited)
Renata Gilbert Makeup Artist
Belinda Hodgson Key Makeup Artist
Sonnyboy Skelton Doxy's Dad (uncredited)