Sofía Vergara Odile Anjelou
Alan Cumming Gutsy Smurf (voice)
Hank Azaria Gargamel
Neil Patrick Harris Patrick Winslow
Frank Welker Azrael (voice)
Kenan Thompson Greedy Smurf (voice)
B. J. Novak Baker Smurf (voice)
Tim Gunn Henri
Sean Kenin Guy in Plaid Shirt
Katy Perry Smurfette (voice)
Jayma Mays Grace Winslow
Tom Kane Narrator Smurf (voice)
Fred Armisen Brainy Smurf (voice)
Sarah Monat Foley Artist
Skai Jackson Kicking Girl
George López Grouchy Smurf (voice)
Joel McCrary Farmer Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Joan Rivers Party Guest
John Cenatiempo Stunts
Heidi Armbruster Toy Store Parent
Gary Basaraba Hefty Smurf (voice)
Jojo Gonzalez FAO Custodian
Christian Wintter Art Direction
Tudor Jones First Assistant Director
John Oliver Vanity Smurf (voice)
Paul Reubens Jokey Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Madison McKinley Model
Chris Cenatiempo Stunts
Frederic Roth First Assistant Director
Jill Brown Stunts
Phil Meheux Director of Photography
Heitor Pereira Original Music Composer
John Speredakos Parent with Girls
Jonathan Winters Papa Smurf (voice)
Victor Pagan Bum
Raja Gosnell Director
Aja Frary Stunts
Andy Hass Animation
Sean Ringgold Inmate Bubba
Mo Henry Negative Cutter
Ezra Swerdlow Executive Producer
John Kassir Crazy Smurf (Voice)
Ronni Brown Foley Artist
Jerad Marantz Makeup Designer
David M. Dunlap Second Unit Director
Jayne Armstrong Post Production Supervisor
G.A. Aguilar Second Unit Director, Stunt Coordinator
Chris Shriver Art Direction
Peter Thorell Second Assistant Director
Shawnna Thibodeau Stunts
Wolfgang Puck Chef Smurf (voice)
Todd Tucker Makeup Designer
Mahadeo Shivraj Cabbie
Conor Kelly Second Second Assistant Director
David N. Weiss Screenplay, Story
Benita Allen First Assistant Director
J. David Stem Screenplay, Story
Julie Chang Newscaster
Bill Boes Production Design
Peyo Characters, Comic Book
Richard Hicks Casting
Mark Doherty Bluetooth Businessman
Mario D'Leon Bubba's Inmate Friend
Bradley Gosnell Toy Salesperson
David Rubin Casting
Tyree Michael Simpson Cop
Sabrina Plisco Editor
Richard Baratta Unit Production Manager
Finnerty Steeves Toy Store Parent
David Ronn Screenplay