Sofía Vergara Odile Anjelou
Hank Azaria Gargamel
Frank Welker Azrael (voice)
Alan Cumming Gutsy Smurf (voice)
George López Grouchy Smurf (voice)
Neil Patrick Harris Patrick Winslow
Paul Reubens Jokey Smurf (voice)
Fred Armisen Brainy Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Katy Perry Smurfette (voice)
Jayma Mays Grace Winslow
Kenan Thompson Greedy Smurf (voice)
John Oliver Vanity Smurf (voice)
B.J. Novak Baker Smurf (voice)
John Cenatiempo Stunts
Joan Rivers Party Guest
John Kassir Crazy Smurf (Voice)
Sean Kenin Guy in Plaid Shirt
Skai Jackson Kicking Girl
Tom Kane Narrator Smurf (voice)
Tim Gunn Henri
Joel McCrary Farmer Smurf (voice)
J. David Stem Screenplay, Story
Jonathan Winters Papa Smurf (voice)
David N. Weiss Story, Screenplay
Gary Basaraba Hefty Smurf (voice)
Madison McKinley Model
Jay Scherick Screenplay
Raja Gosnell Director
John Speredakos Parent with Girls
David Rubin Casting
Richard Hicks Casting
Peyo Characters, Comic Book
David Ronn Screenplay
Mo Henry Negative Cutter
Jeff Foxworthy Handy Smurf (voice)
Heitor Pereira Original Music Composer
Sean Ringgold Inmate Bubba
Heidi Armbruster Toy Store Parent
Jill Brown Stunts
Aja Frary Stunts
Scott Dillin Cop
Mario D'Leon Bubba's Inmate Friend
Wolfgang Puck Chef Smurf (voice)
Jerad Marantz Makeup Designer
Peter Thorell Second Assistant Director
Tudor Jones First Assistant Director
Justin Ritson Additional Second Assistant Director
Tom Colicchio Party Guest
Sabrina Plisco Editor
Michael Musto Party Guest
Shawnna Thibodeau Stunts
Sarah Monat Foley Artist
Victor Pagan Bum
Ronni Brown Foley Artist
Todd Tucker Makeup Designer
Chris Cenatiempo Stunts
G.A. Aguilar Stunt Coordinator, Second Unit Director
David M. Dunlap Second Unit Director
Phil Meheux Director of Photography
Regina Graves Set Decoration
Rita Ryack Costume Design
Mark Doherty Bluetooth Businessman
Mahadeo Shivraj Cabbie
Jojo Gonzalez FAO Custodian
Aaron Williams VFX Artist
Richard Baratta Unit Production Manager
Julie Chang Newscaster
Ezra Swerdlow Executive Producer
Carissa Spatcher Grip
Bradley Gosnell Toy Salesperson
Chris Shriver Art Direction