Sofía Vergara Odile Anjelou
Alan Cumming Gutsy Smurf (voice)
Hank Azaria Gargamel
Neil Patrick Harris Patrick Winslow
Frank Welker Azrael (voice)
Fred Armisen Brainy Smurf (voice)
Tim Gunn Henri
Sean Kenin Guy in Plaid Shirt
Katy Perry Smurfette (voice)
Jayma Mays Grace Winslow
George López Grouchy Smurf (voice)
John Cenatiempo Stunts
Rita Ryack Costume Design
Kenan Thompson Greedy Smurf (voice)
Skai Jackson Kicking Girl
B. J. Novak Baker Smurf (voice)
Joel McCrary Farmer Smurf (voice)
Anton Yelchin Clumsy Smurf (voice)
Joan Rivers Party Guest
Heidi Armbruster Toy Store Parent
Ezra Swerdlow Executive Producer
G.A. Aguilar Second Unit Director, Stunt Coordinator
Sarah Monat Foley Artist
Jojo Gonzalez FAO Custodian
Raja Gosnell Director
Christian Wintter Art Direction
Heitor Pereira Original Music Composer
Gary Basaraba Hefty Smurf (voice)
Aja Frary Stunts
John Oliver Vanity Smurf (voice)
Paul Reubens Jokey Smurf (voice)
John Kassir Crazy Smurf (Voice)
Tom Kane Narrator Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Peter Thorell Second Assistant Director
Adria Baratta Anjelou Employee
Frederic Roth First Assistant Director
Jill Brown Stunts
Phil Meheux Director of Photography
John Speredakos Parent with Girls
Jonathan Winters Papa Smurf (voice)
Victor Pagan Bum
Andy Hass Animation
Sean Ringgold Inmate Bubba
Madison McKinley Model
Ronni Brown Foley Artist
Jayne Armstrong Post Production Supervisor
Regina Graves Set Decoration
Mo Henry Negative Cutter
Benita Allen First Assistant Director
Richard Baratta Unit Production Manager
Wolfgang Puck Chef Smurf (voice)
Chris Cenatiempo Stunts
Todd Tucker Makeup Designer
David M. Dunlap Second Unit Director
Conor Kelly Second Second Assistant Director
David N. Weiss Screenplay, Story
J. David Stem Screenplay, Story
Julie Chang Newscaster
Bill Boes Production Design
Peyo Characters, Comic Book
Shawnna Thibodeau Stunts
Kevin Webb Animation
Richard Hicks Casting
Mahadeo Shivraj Cabbie
Mark Doherty Bluetooth Businessman
Mario D'Leon Bubba's Inmate Friend
Bradley Gosnell Toy Salesperson
David Rubin Casting
Tyree Michael Simpson Cop
Sabrina Plisco Editor
Tudor Jones First Assistant Director