Sofía Vergara Odile Anjelou
Alan Cumming Gutsy Smurf (voice)
Fred Armisen Brainy Smurf (voice)
Hank Azaria Gargamel
Neil Patrick Harris Patrick Winslow
Frank Welker Azrael (voice)
Tim Gunn Henri
Tom Kane Narrator Smurf (voice)
B.J. Novak Baker Smurf (voice)
Jayma Mays Grace Winslow
John Cenatiempo Stunts
G.A. Aguilar Second Unit Director, Stunt Coordinator
Kenan Thompson Greedy Smurf (voice)
Skai Jackson Kicking Girl
Joan Rivers Party Guest
Anton Yelchin Clumsy Smurf (voice)
Heidi Armbruster Toy Store Parent
Katy Perry Smurfette (voice)
George López Grouchy Smurf (voice)
Jojo Gonzalez FAO Custodian
Christian Wintter Art Direction
Joel McCrary Farmer Smurf (voice)
Paul Reubens Jokey Smurf (voice)
Jeff Foxworthy Handy Smurf (voice)
Madison McKinley Model
John Oliver Vanity Smurf (voice)
Sean Kenin Guy in Plaid Shirt
Phil Meheux Director of Photography
Jonathan Winters Papa Smurf (voice)
Victor Pagan Bum
Raja Gosnell Director
Sean Ringgold Inmate Bubba
John Kassir Crazy Smurf (Voice)
Jayne Armstrong Post Production Supervisor
Heitor Pereira Original Music Composer
Todd Tucker Makeup Designer
Conor Kelly Second Second Assistant Director
David N. Weiss Screenplay, Story
Gary Basaraba Hefty Smurf (voice)
Chris Cenatiempo Stunts
J. David Stem Screenplay, Story
Aja Frary Stunts
Sarah Monat Foley Artist
Julie Chang Newscaster
Bill Boes Production Design
David M. Dunlap Second Unit Director
Peyo Characters, Comic Book
Mo Henry Negative Cutter
John Speredakos Parent with Girls
Peter Thorell Second Assistant Director
Wolfgang Puck Chef Smurf (voice)
Mark Doherty Bluetooth Businessman
Shawnna Thibodeau Stunts
Mario D'Leon Bubba's Inmate Friend
Jill Brown Stunts
Bradley Gosnell Toy Salesperson
Tyree Michael Simpson Cop
Ronni Brown Foley Artist
Finnerty Steeves Toy Store Parent
David Rubin Casting
David Ronn Screenplay
Tom Colicchio Party Guest
Ezra Swerdlow Executive Producer
Andrew Sellon Waiter
Jerad Marantz Makeup Designer
Jay Scherick Screenplay
Mahadeo Shivraj Cabbie
Regina Graves Set Decoration
Benita Allen First Assistant Director
Aaron Williams VFX Artist
Richard Baratta Unit Production Manager
Michael Musto Party Guest