Mckenna Grace Young Daphne (voice)
Amanda Seyfried Daphne Blake (voice)
Mark Wahlberg Blue Falcon (voice)
Zac Efron Fred Jones (voice)
Christina Hendricks Officer Jaffe (voice)
Ariana Greenblatt Young Velma (voice)
Iain Armitage Young Shaggy (voice)
Jason Isaacs Dick Dastardly (voice)
Billy West Muttley (voice)
Will Forte Shaggy Rogers (voice)
John DiMaggio Restaurant Owner (voice)
Frank Welker Scooby-Doo / Pterodactyl (voice)
Charles Roven Executive Producer
Ken Jeong Dynomutt, Dog Wonder (voice)
Chris Columbus Executive Producer
Henry Winkler Keith (voice)
Fred Tatasciore Cerberus (voice)
Pierce Gagnon Young Fred (voice)
Eyal Podell Story
Kiersey Clemons Dee Dee Skyes (voice)
Tony Cervone Director, Ghost / Mr. Rigby / Alice (voice)
Dan Povenmire Executive Producer
Justina Machado Jamie Rivera (voice)
Joe Ruby Characters
Ken Spears Characters
Maya Erskine Judy Takamoto (voice)
Ira Glass Ira Glass (voice)
Gina Rodriguez Velma Dinkley (voice)
Tracy Morgan Captain Caveman (voice)
Simon Cowell Simon Cowell (voice)
Matt Lieberman Screenplay, Story
Didier Ah-Koon Storyboard Artist
Ava Max Songs
Adam Sztykiel Officer Casey (voice), Screenplay, Executive Producer
Pam Coats Producer, Mrs. Rogers (voice)
Kevin Heffernan Bike Cop Gary (voice)
Don Messick Muttley (archive sound) (voice)
Jesse Ehrman Executive Producer
Ruth Lambert Casting
Richard Suckle Executive Producer
Jack Harlow Songs
Chiranjiv Makwana Screenplay
Michael Kurinsky Production Design, Samuel Colton (voice)
Gabe Hilfer Music Supervisor
Joe Haidar Storyboard Artist
Tom Ruegger Art Designer, Visual Effects Designer
Charlie Puth Songs
Allison Abbate Producer
Tom Holkenborg Original Music Composer
Jack Donaldson Screenplay
Danelle Davenport Storyboard Artist
Emil Mitev Art Direction
Ryan Folsey Editor, Beach Guy (voice)
Ricardo F. Delgado Storyboard Artist
Henry Kaufman Chad / Chet (voice)
Harry Perry Harry Perry (voice)
Maven Morgan Kari (voice)
Derek Elliott Screenplay
Rico Nasty Songs
Jonathon E. Stewart Story
Tony Cosanella Co-Producer
Timothy Jason Smith Associate Producer
Pink Sweat$ Songs
Noëlle Raffaele Story Artist
Vanara Taing Baby Rotten (voice), Editor
Bill Haller Head of Animation
Mike Fortner CG Supervisor
Andy Horwitz Executive Producer
Sarah Lancia Dispatcher Stevens (voice)
Rafael Zentil Head of Story
Alex Kauffman Officer North (voice)
Kennedy Peil Indira Knight (voice)