Mark Wahlberg Blue Falcon (voice)
Mckenna Grace Young Daphne (voice)
Amanda Seyfried Daphne Blake (voice)
Will Forte Shaggy Rogers (voice)
Jason Isaacs Dick Dastardly (voice)
Zac Efron Fred Jones (voice)
Iain Armitage Young Shaggy (voice)
Christina Hendricks Officer Jaffe (voice)
Billy West Muttley (voice)
Simon Cowell Simon Cowell (voice)
Henry Winkler Keith (voice)
Justina Machado Jamie Rivera (voice)
Frank Welker Scooby-Doo / Pterodactyl (voice)
Eyal Podell Story
Ariana Greenblatt Young Velma (voice)
John DiMaggio Restaurant Owner (voice)
Tony Cervone Ghost / Mr. Rigby / Alice (voice), Director
Dan Povenmire Executive Producer
Ken Jeong Dynomutt, Dog Wonder (voice)
Joe Ruby Characters
Ken Spears Characters
Ira Glass Ira Glass (voice)
Chris Columbus Executive Producer
Tracy Morgan Captain Caveman (voice)
Gina Rodriguez Velma Dinkley (voice)
Richard Suckle Executive Producer
Kiersey Clemons Dee Dee Skyes (voice)
Maya Erskine Judy Takamoto (voice)
Allison Abbate Producer
Didier Ah-Koon Storyboard Artist
Pierce Gagnon Young Fred (voice)
Fred Tatasciore Cerberus (voice)
Pam Coats Mrs. Rogers (voice), Producer
Kevin Heffernan Bike Cop Gary (voice)
Don Messick Muttley (archive sound) (voice)
Tom Holkenborg Original Music Composer
Ava Max Songs
Adam Sztykiel Officer Casey (voice), Executive Producer, Screenplay
Jack Donaldson Screenplay
Jack Harlow Songs
Rafael Zentil Head of Story
Charles Roven Executive Producer
Joe Haidar Storyboard Artist
Tom Ruegger Visual Effects Designer, Art Designer
Charlie Puth Songs
Ruth Lambert Casting
Gabe Hilfer Music Supervisor
Matt Lieberman Screenplay, Story
Chiranjiv Makwana Screenplay
Ryan Folsey Beach Guy (voice), Editor
Ricardo F. Delgado Storyboard Artist
Danelle Davenport Storyboard Artist
Henry Kaufman Chad / Chet (voice)
Harry Perry Harry Perry (voice)
Jesse Ehrman Executive Producer
Derek Elliott Screenplay
Emil Mitev Art Direction
Rico Nasty Songs
Jonathon E. Stewart Story
Tony Cosanella Co-Producer
Timothy Jason Smith Associate Producer
Michael Kurinsky Samuel Colton (voice), Production Design
Pink Sweat$ Songs
Noëlle Raffaele Story Artist
Vanara Taing Baby Rotten (voice), Editor
Bill Haller Head of Animation
Mike Fortner CG Supervisor
Andy Horwitz Executive Producer
Maven Morgan Kari (voice)
Sarah Lancia Dispatcher Stevens (voice)
Alex Kauffman Officer North (voice)
Kennedy Peil Indira Knight (voice)