Mckenna Grace Young Daphne (voice)
Amanda Seyfried Daphne Blake (voice)
Zac Efron Fred Jones (voice)
Mark Wahlberg Blue Falcon (voice)
Iain Armitage Young Shaggy (voice)
John DiMaggio Restaurant Owner (voice)
Jason Isaacs Dick Dastardly (voice)
Chris Columbus Executive Producer
Justina Machado Jamie Rivera (voice)
Will Forte Shaggy Rogers (voice)
Ariana Greenblatt Young Velma (voice)
Christina Hendricks Officer Jaffe (voice)
Maya Erskine Judy Takamoto (voice)
Frank Welker Scooby-Doo / Pterodactyl (voice)
Fred Tatasciore Cerberus (voice)
Ken Jeong Dynomutt (voice)
Henry Winkler Keith (voice)
Tracy Morgan Captain Caveman (voice)
Kiersey Clemons Dee Dee Skyes (voice)
Gina Rodriguez Velma Dinkley (voice)
Simon Cowell Simon Cowell (voice)
Billy West Muttley (voice)
Eyal Podell Story
Dan Povenmire Executive Producer
Kevin Heffernan Bike Cop Gary (voice)
Joe Ruby Characters
Pierce Gagnon Young Fred (voice)
Matt Lieberman Screenplay, Story
Don Messick Muttley (archive sound) (voice)
Ira Glass Ira Glass (voice)
Adam Sztykiel Officer Casey (voice), Screenplay, Executive Producer
Gabe Hilfer Music Supervisor
Tom Holkenborg Original Music Composer
Jack Harlow Songs
John Puglisi Additional Storyboarding
Charlie Puth Songs
Charles Roven Executive Producer
Tony Cervone Director, Ghost / Mr. Rigby / Alice (voice)
Tom Ruegger Art Designer, Visual Effects Designer
Ava Max Songs
Ruth Lambert Casting
Pam Coats Producer, Mrs. Rogers (voice)
Vanara Taing Baby Rotten (voice), Editor
Lex Cassar Visual Development
Ryan Folsey Beach Guy (voice), Editor
Ken Spears Characters
Allison Abbate Producer
Jonathon E. Stewart Story
Richard Suckle Executive Producer
Mark Garcia Story Artist
Andy Horwitz Executive Producer
Noëlle Raffaele Additional Storyboarding, Story Artist
Emil Mitev Art Direction
Tony Cosanella Co-Producer
Delia Gosman Story Artist
Gabriel Lin Story Artist
Harry Perry Harry Perry (voice)
Rico Nasty Songs
Jack C. Donaldson Screenplay
Danelle Davenport Additional Storyboarding
Ethan Hegge Story Artist
Derek Elliott Screenplay
Athanassios Vakalis Story Artist
Padraig Collins Story Artist
Sahin Ersöz Additional Storyboarding
Henry Kaufman Chad / Chet (voice)
Alex Kauffman Officer North (voice)
Pink Sweat$ Songs
Michael Kurinsky Samuel Colton (voice), Production Design
Rafael Zentil Head of Story
Maven Morgan Kari (voice)
Mike Fortner CG Supervisor