Mckenna Grace Young Daphne (voice)
Mark Wahlberg Blue Falcon (voice)
Amanda Seyfried Daphne Blake (voice)
Ariana Greenblatt Young Velma (voice)
Zac Efron Fred Jones (voice)
Iain Armitage Young Shaggy (voice)
Christina Hendricks Officer Jaffe (voice)
Jason Isaacs Dick Dastardly (voice)
Billy West Muttley (voice)
John DiMaggio Restaurant Owner (voice)
Simon Cowell Simon Cowell (voice)
Henry Winkler Keith (voice)
Justina Machado Jamie Rivera (voice)
Will Forte Shaggy Rogers (voice)
Frank Welker Scooby-Doo / Pterodactyl (voice)
Eyal Podell Story
Tony Cervone Director, Ghost / Mr. Rigby / Alice (voice)
Dan Povenmire Executive Producer
Joe Ruby Characters
Kiersey Clemons Dee Dee Skyes (voice)
Ken Spears Characters
Chris Columbus Executive Producer
Ken Jeong Dynomutt, Dog Wonder (voice)
Ira Glass Ira Glass (voice)
Gina Rodriguez Velma Dinkley (voice)
Maya Erskine Judy Takamoto (voice)
Fred Tatasciore Cerberus (voice)
Tracy Morgan Captain Caveman (voice)
Allison Abbate Producer
Didier Ah-Koon Storyboard Artist
Pierce Gagnon Young Fred (voice)
Pam Coats Producer, Mrs. Rogers (voice)
Jack Donaldson Screenplay
Kevin Heffernan Bike Cop Gary (voice)
Don Messick Muttley (archive sound) (voice)
Ava Max Songs
Adam Sztykiel Officer Casey (voice), Screenplay, Executive Producer
Charles Roven Executive Producer
Jack Harlow Songs
Rafael Zentil Head of Story
Tom Holkenborg Original Music Composer
Joe Haidar Storyboard Artist
Tom Ruegger Art Designer, Visual Effects Designer
Charlie Puth Songs
Ruth Lambert Casting
Matt Lieberman Screenplay, Story
Gabe Hilfer Music Supervisor
Richard Suckle Executive Producer
Chiranjiv Makwana Screenplay
Ryan Folsey Editor, Beach Guy (voice)
Ricardo F. Delgado Storyboard Artist
Danelle Davenport Storyboard Artist
Henry Kaufman Chad / Chet (voice)
Harry Perry Harry Perry (voice)
Jesse Ehrman Executive Producer
Derek Elliott Screenplay
Emil Mitev Art Direction
Rico Nasty Songs
Michael Kurinsky Production Design, Samuel Colton (voice)
Jonathon E. Stewart Story
Tony Cosanella Co-Producer
Timothy Jason Smith Associate Producer
Pink Sweat$ Songs
Noëlle Raffaele Story Artist
Vanara Taing Baby Rotten (voice), Editor
Bill Haller Head of Animation
Mike Fortner CG Supervisor
Andy Horwitz Executive Producer
Maven Morgan Kari (voice)
Sarah Lancia Dispatcher Stevens (voice)
Alex Kauffman Officer North (voice)
Kennedy Peil Indira Knight (voice)