Tom Cruise Frank T.J. Mackey
Julianne Moore Linda Partridge
Jim Beaver Smiling Peanut Patron #1
William H. Macy Quiz Kid Donnie Smith
Thomas Jane Young Jimmy Gator
Luis Guzmán Luis
Philip Seymour Hoffman Phil Parma
Pat Healy Sir Edmund William Godfrey / Young Pharmacy Kid
Mary Lynn Rajskub Janet (Frank's Assistant) (voice)
Paul Thomas Anderson Director, Writer, Man Confiscating Sign (uncredited), Producer
Patton Oswalt Delmer Darion
John C. Reilly Officer Jim Kurring
Alfred Molina Solomon Solomon
Paul F. Tompkins Chad (Seduce & Destroy) (voice)
Jim Meskimen Forensic Scientist
Miriam Margolyes Faye Barringer (uncredited)
Allan Graf Stunts, Firefighter
Clark Gregg WDKK Floor Director
Cleo King Marcie
Henry Gibson Thurston Howell
Orlando Jones Worm
Melora Walters Claudia Wilson Gator
Michael Murphy Alan Kligman, Esq.
Neil Flynn Stanley Berry
Meagen Fay Dr. Diane
Jason Robards Earl Partridge
Felicity Huffman Cynthia
Lynn Harris Executive Producer
William Mapother WDKK Show Director's Assistant
Philip Baker Hall Jimmy Gator
Matt Gerald Officer #2
Melinda Dillon Rose Gator
Michael Bowen Rick Spector
Tom Ohmer Detective (uncredited)
Colin Brady Animation
Don McManus Dr. Landon
Kevin Breznahan Geoff, Seminar Guy
Dennis Scott Stunts
Jon Brion Original Music Composer
Rod McLachlan Daniel Hill
Scott Alan Smith E.R. Doctor
Ezra Buzzington Smiling Peanut Patron #2
Jim Ortlieb Middle-Aged Guy
Christopher Flick Foley Supervisor
Brad Hunt Craig Hansen
Robert Downey Sr. WDKK Show Director
April Grace Gwenovier
Michael Shamus Wiles Captain Muffy
Ricky Jay Burt Ramsey / Narrator
Ousaun Elam Stunts
Guy Norman Bee Steadicam Operator
Barbara Harris ADR Voice Casting
Chris O'Hara Sydney Barringer
Adam Druxman First Assistant Director
Dan Rebert Special Effects Supervisor
Richard King Sound Designer, Supervising Sound Editor
Spencer Kayden Seminar Patron (uncredited)
Chanel Salzer Assistant Location Manager
Lindy DeQuattro Visual Effects
Harry Wowchuk Stunts
John Moio Stunts
Clement Blake Arthur Barringer
Art Frankel Old Pharmacist
Webster Whinery Stunt Coordinator
Blumes Tracy Special Effects
Selina Jayne Makeup Artist
Greg Bronson Waiter (uncredited)
Lou Carlucci Special Effects Supervisor
Tina Roesler Kerwin Key Makeup Artist
Aimee Mann Songs, Hot Date Infomercial (uncredited)
Lillian Adams Donnie's Old Neighbor
R. Michael De Chellis Best Boy Electric