Tom Cruise Frank T.J. Mackey
Julianne Moore Linda Partridge
Alfred Molina Solomon Solomon
William H. Macy Quiz Kid Donnie Smith
Patton Oswalt Delmer Darion
Philip Seymour Hoffman Phil Parma
Luis Guzmán Luis
John C. Reilly Officer Jim Kurring
Paul Thomas Anderson Director, Writer, Man Confiscating Sign (uncredited), Producer
Thomas Jane Young Jimmy Gator
Neil Flynn Stanley Berry
Mary Lynn Rajskub Janet (Frank's Assistant) (voice)
William Mapother WDKK Show Director's Assistant
Clark Gregg WDKK Floor Director
Jim Beaver Smiling Peanut Patron #1
Michael Bowen Rick Spector
Orlando Jones Worm
Miriam Margolyes Faye Barringer (uncredited)
Matt Gerald Officer #2
Jason Robards Earl Partridge
Felicity Huffman Cynthia
Philip Baker Hall Jimmy Gator
Jim Meskimen Forensic Scientist
Paul F. Tompkins Chad (Seduce & Destroy) (voice)
Melora Walters Claudia Wilson Gator
Richard King Sound Designer, Supervising Sound Editor
Chris O'Hara Sydney Barringer
Melinda Dillon Rose Gator
Michael Murphy Alan Kligman, Esq.
Don McManus Dr. Landon
April Grace Gwenovier
Allan Graf Stunts, Firefighter
Jennifer Clark Assistant Accountant
Cleo King Marcie
Michael Shamus Wiles Captain Muffy
Pat Healy Sir Edmund William Godfrey / Young Pharmacy Kid
Michael De Luca Executive Producer
Cassandra Kulukundis Casting
Kevin Breznahan Geoff, Seminar Guy
Ricky Jay Burt Ramsey / Narrator
Meagen Fay Dr. Diane
Spencer Kayden Seminar Patron (uncredited)
Miguel Pérez Avi Solomon
Joe Letteri Visual Effects Supervisor
Barbara Harris ADR Voice Casting
Dennis Sands Scoring Mixer
Jim Ortlieb Middle-Aged Guy
Robert Downey Sr. WDKK Show Director
Dan O'Connell Foley Artist
Rod McLachlan Daniel Hill
Ezra Buzzington Smiling Peanut Patron #2
Dana Sano Music Supervisor
Robert Elswit Director of Photography
Henry Gibson Thurston Howell
Scott Alan Smith E.R. Doctor
Michael Semanick Sound Re-Recording Mixer
Jon Brion Original Music Composer
Colin Brady Animation
Clement Blake Arthur Barringer
Terry Jackson Stunts
Mark Graziano Post Production Supervisor
Lillian Adams Donnie's Old Neighbor
John Pritchett Sound Mixer, Police Captain
Greg Bronson Waiter (uncredited)
John Moio Stunts
Dylan Tichenor Editor, Associate Producer
Debbie Evans Stunts
James Ashwill Foley Mixer
William Arnold Production Design
Christopher Flick Foley Supervisor
Hans Bjerno Aerial Camera
Lynn Harris Executive Producer