Tom Cruise Frank T.J. Mackey
Julianne Moore Linda Partridge
Alfred Molina Solomon Solomon
Paul Thomas Anderson Director, Writer, Man Confiscating Sign (uncredited), Producer
Philip Seymour Hoffman Phil Parma
Patton Oswalt Delmer Darion
William H. Macy Quiz Kid Donnie Smith
Miriam Margolyes Faye Barringer (uncredited)
John C. Reilly Officer Jim Kurring
Michael Murphy Alan Kligman, Esq.
Thomas Jane Young Jimmy Gator
Ricky Jay Burt Ramsey / Narrator
Luis Guzmán Luis
Clark Gregg WDKK Floor Director
Michael Bowen Rick Spector
Richard King Sound Designer, Supervising Sound Editor
Jim Beaver Smiling Peanut Patron #1
William Mapother WDKK Show Director's Assistant
Paul F. Tompkins Chad (Seduce & Destroy) (voice)
Jim Meskimen Forensic Scientist
Mary Lynn Rajskub Janet (Frank's Assistant) (voice)
Matt Gerald Officer #2
Melora Walters Claudia Wilson Gator
Neil Flynn Stanley Berry
Philip Baker Hall Jimmy Gator
Chris O'Hara Sydney Barringer
Allan Graf Stunts, Firefighter
Pat Healy Sir Edmund William Godfrey / Young Pharmacy Kid
Don McManus Dr. Landon
Orlando Jones Worm
Cleo King Marcie
Lois Burwell Makeup Artist
April Grace Gwenovier
Jason Robards Earl Partridge
Michael De Luca Executive Producer
Felicity Huffman Cynthia
Joe Letteri Visual Effects Supervisor
Michael Semanick Sound Re-Recording Mixer
Michael Shamus Wiles Captain Muffy
Doc Kane ADR Mixer
Melinda Dillon Rose Gator
Cassandra Kulukundis Casting
Meagen Fay Dr. Diane
Robert Elswit Director of Photography
Miguel Pérez Avi Solomon
Richard Burden Stunts
Dale Gibson Paramedic #3
Greg Bronson Waiter (uncredited)
Jennifer Clark Assistant Accountant
Robert Downey Sr. WDKK Show Director
Spencer Kayden Seminar Patron (uncredited)
Christopher Allen Nelson Special Effects Makeup Artist
Jim Ortlieb Middle-Aged Guy
Andrew M. Siegel Props
Kevin Breznahan Geoff, Seminar Guy
John Pritchett Sound Mixer, Police Captain
Dylan Tichenor Editor, Associate Producer
Robert J. Litt Sound Re-Recording Mixer
Lillian Adams Donnie's Old Neighbor
Ezra Buzzington Smiling Peanut Patron #2
Barbara Harris ADR Voice Casting
Scott Alan Smith E.R. Doctor
Clement Blake Arthur Barringer
Colin Brady Animation
Dan O'Connell Foley Artist
Shepherd Frankel Assistant Art Director
Kimberly Harris ADR Supervisor
Dana Sano Music Supervisor
Jon Brion Original Music Composer
Lynn Harris Executive Producer
William Arnold Production Design
James Ashwill Foley Mixer