Tom Cruise Frank T.J. Mackey
Julianne Moore Linda Partridge
William H. Macy Quiz Kid Donnie Smith
Alfred Molina Solomon Solomon
Luis Guzmán Luis
Philip Seymour Hoffman Phil Parma
Patton Oswalt Delmer Darion
Clark Gregg WDKK Floor Director
John C. Reilly Officer Jim Kurring
Neil Flynn Stanley Berry
Thomas Jane Young Jimmy Gator
Mary Lynn Rajskub Janet (Frank's Assistant) (voice)
Jim Beaver Smiling Peanut Patron #1
Paul Thomas Anderson Director, Writer, Man Confiscating Sign (uncredited), Producer
Orlando Jones Worm
Miriam Margolyes Faye Barringer (uncredited)
Jason Robards Earl Partridge
Felicity Huffman Cynthia
William Mapother WDKK Show Director's Assistant
Philip Baker Hall Jimmy Gator
Melinda Dillon Rose Gator
Matt Gerald Officer #2
Melora Walters Claudia Wilson Gator
Jennifer Clark Assistant Accountant
Don McManus Dr. Landon
Michael Murphy Alan Kligman, Esq.
Cleo King Marcie
Michael Bowen Rick Spector
Meagen Fay Dr. Diane
Paul F. Tompkins Chad (Seduce & Destroy) (voice)
Pat Healy Sir Edmund William Godfrey / Young Pharmacy Kid
Jim Meskimen Forensic Scientist
Thomas J. O'Connell ADR Mixer
Michael De Luca Executive Producer
Michael Shamus Wiles Captain Muffy
Henry Gibson Thurston Howell
Allan Graf Stunts, Firefighter
Ricky Jay Burt Ramsey / Narrator
Chris O'Hara Sydney Barringer
April Grace Gwenovier
Robert Downey Sr. WDKK Show Director
Dan O'Connell Foley Artist
Guy Norman Bee Steadicam Operator
Richard King Sound Designer, Supervising Sound Editor
John T. Cucci Foley Artist
Barbara Harris ADR Voice Casting
John S. Davies Cameraman
Ezra Buzzington Smiling Peanut Patron #2
Michael Semanick Sound Re-Recording Mixer
Scott Alan Smith E.R. Doctor
Debbie Evans Stunts
Miguel Pérez Avi Solomon
Tom Ohmer Detective (uncredited)
Ben Beaird Key Grip
Rick Seaman Stunts
Greg Bronson Waiter (uncredited)
Jim Ortlieb Middle-Aged Guy
Robert Elswit Director of Photography
Christopher Allen Nelson Special Effects Makeup Artist
Clement Blake Arthur Barringer
Paul Avery Electrician
Brad Hunt Craig Hansen
Daniel Lupi Co-Producer, Unit Production Manager
Lillian Adams Donnie's Old Neighbor
Doc Kane ADR Mixer
Kevin Breznahan Geoff, Seminar Guy
Eileen Malyszko Lee Production Coordinator
Dylan Tichenor Editor, Associate Producer
Michael Lee Phillips Jr. Set Production Assistant, Mackey Disciple in Middle
Joe Letteri Visual Effects Supervisor
Andrew M. Siegel Props
Terry Jackson Stunts