Bradley Cooper Holden Wilson
Anne Hathaway Liz Curran
Jessica Alba Morley Clarkson
Julia Roberts Captain Kate Hazeltine
Jennifer Garner Julia Fitzpatrick
Jamie Foxx Kelvin Moore
Eric Dane Sean Jackson
George López Alphonso Rodriguez
Queen Latifah Paula Thomas
Jessica Biel Kara Monahan
Taylor Swift Felicia Miller
Patrick Dempsey Dr. Harrison Copeland
Topher Grace Jason Morris
Ashton Kutcher Reed Bennett
Emma Roberts Grace Smart
Kathy Bates Susan Milton
Paul Williams Romeo Midnight (voice)
Héctor Elizondo Edgar Paddington
Joe Mantegna Angry Driver (uncredited)
Shirley MacLaine Estelle Paddington
Kristen Schaal Ms. Gilroy
Larry Miller Oversized Baggage Agent
Aramis Knight (uncredited)
Katherine LaNasa Pamela Copeland
Taylor Lautner Willy Harrington
Rance Howard Bistro Gardens Diner
Cleo King TSA Supervisor Daisy Bell
Megan Suri Rani
Carter Jenkins Alex Franklin
Garry Marshall Director, Musician (uncredited)
Marc Silverstein Writer
Sandra Taylor Beach Girl Candy
Bonnie Aarons Strange Lady
Calvin Jung Flower Mart Simon
Sarah Lilly Lady With Dog
Mark Mangini Sound Designer, Supervising Sound Editor
Abby Kohn Writer
Emily Moss Wilson Kissing Girl (uncredited)
Wayne Allan Rice Producer
Andy Gill Stunts
Howard Storm Louder Guy
Guilford Adams Vista Movie Theatre Owner (uncredited)
Alexis Kendra Friend Dana
Emily Arlook Skater Girl (uncredited)
Gary Jones Costume Design
Doug Hemphill Sound Re-Recording Mixer
Derek Theler Masseur (uncredited)
Hans Marrero Stunts, Gardner (uncredited)
Jennifer Leigh Warren Party Singer
Erin Matthews Flight Attendant
Ron Bartlett Sound Re-Recording Mixer
Jonathan Morgan Heit Tough Franklin
Barbara Marshall Head Nurse
Larrs Jackson Chauffer Redmond
Kamilla Bjorlin Sherry Donaldson
Eddie J. Fernandez Stunt Double
John Debney Original Music Composer
Hannah Storm ESPN Hannah Storm
Tracy Reiner French Photographer
Toby Emmerich Executive Producer
Matthew Walker Greg Gilkins
Faline England Flower Shop Customer #1
Paul Vogt Shouting Sheldon
Brooklynn Proulx Madison
Lisa Roberts Gillan Young Nurse
Travina Springer Sign Language Interpreter
Deborah Aquila Casting
Matt Merchant Loud Guy
Beth Kennedy Mrs. Claudia Smart
Kathleen Marshall Nikki
Bruce Green Editor
Angie Patterson Nanny (uncredited)