Channing Tatum Joaquin (voice)
Zoe Saldaña Maria (voice)
Ron Perlman Xibalba (voice)
Guillermo del Toro Land of the Remembered Captain's Wife (voice), Producer
Danny Trejo Skeleton Luis (voice)
Diego Luna Manolo (voice)
Ice Cube Candle Maker (voice)
Grey DeLisle Grandmother (voice) (as Grey Griffin)
Ana de la Reguera Carmen Sánchez (voice)
Christina Applegate Mary Beth (voice)
Carlos Alazraqui General Posada / Dali / Chuy (voice)
Héctor Elizondo Carlos Sanchez (voice)
Eugenio Derbez Chato (voice)
Cheech Marin Pancho Rodriguez (voice)
Eric Bauza Father Domingo / Cave Guardian (voice)
Troy Evans Old Man Hemingway (voice)
Gabriel Iglesias Pepe Rodriguez (voice)
Miguel Sandoval Land of the Remembered Captain (voice)
Anjelah Johnson-Reyes Adelita / Nina (voice)
Kate del Castillo La Muerte (voice)
Aron Warner Thomas (voice), Executive Producer
Sandra Equihua Character Designer, Scardelita (voice)
Moosie Drier Additional Voices (voice)
Elijah Rodriguez Young Joaquin
David Cowgill Additional Voices (voice)
Vicki Davis Additional Voices (voice)
Plácido Domingo Skeleton Jorge (voice)
Angélica María Sister Ana (voice)
Dan O'Connell Foley
Mark Mangini Additional Sound Re-Recording Mixer
John T. Cucci Foley
Cullen McCarthy Additional Voices (voice)
Ruth Zalduondo Additional Voices (voice)
Newell Alexander Additional Voices (voice)
Marcelo Tubert Additional Voices (voice)
Eva Bella Additional Voices (voice)
Jonathan Nichols-Navarro Additional Voices (voice)
Al Rodrigo Additional Voices (voice)
Gustavo Santaolalla Original Music Composer
Scott Martin Gershin Supervising Sound Editor
Elisa Gabrielli Additional Voices (voice)
James Ashwill Foley
Arthur Ortiz Additional Voices (voice)
Sandra Echeverría Claudia (voice)
Beau Borders Sound Re-Recording Mixer
Doug Langdale Writer
Blake Collins Foley
Scott Wolf Sound Effects Editor
Steve Alterman Additional Voices (voice)
Michael Miller ADR & Dubbing
David Michie Additional Voices (voice)
Jessie Pariseau First Assistant Sound Editor
Lynnanne Zager Additional Voices (voice)
Tom Caulfield Character Designer
Andy Koyama Sound Re-Recording Mixer
Rosemary Alexander Additional Voices (voice)
David Arch Musician
Stephen P. Robinson Sound Designer
Rachel Bolt Musician
John Houlihan Music Supervisor
Jeff Carson Music Editor
Christian Kaplan Casting
Gunnar Sizemore Ignacio (voice)
Jorge R. Gutierrez Skeleton Carmelo (voice), Character Designer, Additional Music, Director, Writer, Playback Singer
Tonita Castro La Muerte as Old Woman (voice)
Tim Walston Sound Designer
Nicholas Bucknall Musician
Tim Davies Conductor
Charles Martin Inouye Music Editor
Christopher T. Welch ADR Editor
Wesley Mandell Lighting Artist
Germaine Franco Additional Music, Orchestrator