
Born in The Bronx, New York, Buono was raised in a blue-collar family and decided at an early age to make acting her life's ambition. At 11, she showed her connection to her family's work ethic by answering a casting call ad for Harvey Fierstein's "Spookhouse" and landing the role, without any assistance from her family or other adults. Buono began landing roles on television and the New York stage while in her teens and early twenties, and earned a Daytime Emmy nomination as a young victim of sexual abuse in Abby, My Love (1991) (CBS, 1991), which aired as part of the CBS Schoolbreak Special (1984). She soon graduated to minor roles in Stephen Gyllenhaal's Waterland (1992), with Jeremy Irons and Ethan Hawke; as an illegal immigrant in The Cowboy Way (1994), with Woody Harrelson and Kiefer Sutherland; and in Noah Baumbach's much-loved indie comedy, Kicking and Screaming (1995), which reunited her with her "Abby, My Love" co-star, Josh Hamilton. While cultivating her acting career, Buono also graduated from Columbia University with a double major in English and political science in 1995, which she earned in just three years.
After graduation, Buono concentrated largely on character roles in independent films and on television. She was the wife and confidante of prison guard Robert Sean Leonard, who served as an earpiece for monstrous 1930s criminal Carl Panzram (James Woods) in Killer: A Journal of Murder (1995), before playing an accident-prone opera singer in love with a young man (Gibson Frazier) with Jazz-Era affectations in the offbeat Man of the Century (1999). She soon added behind-the-camera credits to her expanding resume, including writer/director on the short, Baggage (1997), with Liev Schreiber and Minnie Driver, and served as co-producer and star of the comedy, Two Ninas (1999), about a pair of similarly monikered women (Buono and Amanda Peet) who fell for a very unlucky man. She continues to write and co-wrote "When the Cat's Away" (1999), with Brad Anderson, and wrote an adaptation of F. Scott Fitzgerald's first novel, "This Side of Paradise".
Buono's screen credits grew more obscure at the launch of the new millennium - art house and film festival circles saw the lesbian drama, Chutney Popcorn (1999), Attention Shoppers (2000), Happy Accidents (2000) with Marisa Tomei and Vincent D'Onofrio. She soon turned to television for wider exposure, and earned it through supporting roles on high profile series like Third Watch (1999) and The Sopranos (1999). In 2007, she joined the cast of the cult favorite, The Dead Zone (2002) (USA, 2002-2007) as Sheriff Anna Turner, who investigated the death of her predecessor (Chris Bruno).
During this period, Buono maintained her screen career in features as varied as Ang Lee's Hulk (2003), playing David Banner's mother, who was killed by his genetically-induced rage, and Beer League (2006), and Artie Lange's hapless lay-about love interest. In 2010, she appeared as the divorced mother of Kodi Smit-McPhee in Let Me In (2010), the critically-praised American remake of the Swedish vampire movie, Let the Right One In (2008). That same year, she landed her most widely seen role-to-date on Mad Men (2007), playing Dr. Faye Miller. For her efforts, Buono received an Emmy Award nomination for Outstanding Guest Actress in a Drama Series in 2011.
14.6
Popularity43
Credits6.4
Rating49.7M
Budget110M
RevenueActing
Primarily
2026 One Last Adventure: The Making of Stranger Things 5 as Self - Karen Wheeler
2025 Things Like This as Margie Kitlin
2025 V13 as Ida
2025 Queen of the Ring as Bertha
2024 In Fidelity as Holly Ayker
2024 Always, Already as Cara
2023 The Girl Who Escaped: The Kara Robinson Story as Debra
2023 She Came from the Woods as Heather McCalister Producer
2018 Monsters and Men as Stacey
2018 The Bad Seed as Angela
2017 All Saints as Aimee Spurlock
2016 Half the Perfect World as Sonia
2015 Emily & Tim as Emily (Segment 3)
2015 Paper Towns as Mrs. Jacobsen
2014 A Good Marriage as Betty Pike
2014 The Discoverers as Nell
2014 Drew Peterson: Untouchable as Kathleen Savio
2012 Modern Love as Nicky
2010 Let Me In as Owen's Mother
2010 Betrayed as Amy Waite
2008 Cthulhu as Dannie
2008 The Unquiet as Julie Bishop
2006 Beer League as Linda
2004 From Other Worlds as Joanne
2003 Hulk as Edith Banner
2001 Chutney Popcorn as Janis
2000 Two Ninas as Nina Cohen
2000 Attention Shoppers as Claire Suavez
2000 Takedown as Christina Painter
2000 Happy Accidents as Bette
1999 Man of the Century as Virginia Clemens
1999 In a Class of His Own as Sherry Donato
1999 Deep in My Heart as Young Gerry Cummins
1998 River Red as Rachel
1998 Next Stop Wonderland as Julie
1997 Baggage Director, Writer, Producer
1996 Killer: A Journal of Murder as Esther Lesser
1995 Kicking and Screaming as Kate
1994 The Cowboy Way as Teresa Salazar
1993 Victim of Love: The Shannon Mohr Story as Tracey Lien
1993 In the Line of Duty: Ambush in Waco
1992 Waterland as Judy Dobson
1992 Gladiator as Dawn